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Activity of quercetin and kaemferol against Streptococcus mutans biofilm.
Zeng, Yan; Nikitkova, Anna; Abdelsalam, Hossam; Li, Jiyao; Xiao, Jin.
Afiliación
  • Zeng Y; Eastman Institute for Oral Health, University of Rochester Medical Center, Rochester, NY, 14618, USA; Department of Forensic Medicine, North Sichuan Medical College, China.
  • Nikitkova A; Eastman Institute for Oral Health, University of Rochester Medical Center, Rochester, NY, 14618, USA.
  • Abdelsalam H; Eastman Institute for Oral Health, University of Rochester Medical Center, Rochester, NY, 14618, USA.
  • Li J; State Key Laboratory of Oral Diseases, West China College of Stomatology, Sichuan University, Chengdu, 610041, China. Electronic address: jiyaoliscu@163.com.
  • Xiao J; Eastman Institute for Oral Health, University of Rochester Medical Center, Rochester, NY, 14618, USA. Electronic address: jin_xiao@urmc.rochester.edu.
Arch Oral Biol ; 98: 9-16, 2019 Feb.
Article en En | MEDLINE | ID: mdl-30419487
OBJECTIVE: Nidus Vespae (NV) is the honeycomb of Polistes Olivaceous, P. Japonicus Saussure, and Parapolybiavaria Fabricius. Previously, we have shown the extract and chemical fractions from NV demonstrated remarkable capacities of inhibiting the acid production of oral bacteria at sub-minimum inhibitory concentration (MIC) concentrations. In searching the most potent anti-caries compounds in NV, we further separated the NV Chl/MeOH fraction and obtained two purified compounds: quercetin and kaemferol. The objective of this study was to assess the effectiveness of quercetin and kaemferol against S. mutans biofilm formation. METHODS: The MIC, minimum biofilm inhibition concentration (MBIC50) and minimum biofilm reduction concentration (MBRC50) against Streptococcus mutans were examined for NV-derived of quercetin and kaemferol. The effectiveness of inhibiting S. mutans biofilm formation was further examined using in vitro biofilm model. RESULTS: Both quercetin and kaemferol compounds demonstrated anti-biofilm activities when compared to the negative control. They are capable of reducing biofilm dry-weight, total protein, viable cells measured by colony forming unit (CFU), insoluble and soluble glucans formation. The in situ culture pH was less acidic when the biofilms were treated by quercetin and kaemferol. The quercetin and kaemferol demonstrated comparable capability of S. mutans killing in biofilms, compared to chlorhexidine. CONCLUSIONS: The results of this study showed inhibitory activity of quercetin and kaemferol against S. mutans biofilms, suggesting that quercetin and kaemferol might be considered as alternative anti-caries agents in searching novel anti-caries therapeutics.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Quercetina / Streptococcus mutans / Biopelículas / Quempferoles / Antibacterianos Idioma: En Revista: Arch Oral Biol Año: 2019 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Quercetina / Streptococcus mutans / Biopelículas / Quempferoles / Antibacterianos Idioma: En Revista: Arch Oral Biol Año: 2019 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido