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Dosimetric and radiobiological comparison in different dose calculation grid sizes between Acuros XB and anisotropic analytical algorithm for prostate VMAT.
Kim, Kyeong-Hyeon; Chung, Jin-Beom; Suh, Tae Suk; Kang, Sang-Won; Kang, Seong-Hee; Eom, Keun-Yong; Song, Changhoon; Kim, In-Ah; Kim, Jae-Sung.
Afiliación
  • Kim KH; Department of Biomedicine & Health Sciences, Research Institute of Biomedical Engineering, College of Medicine, the Catholic University of Korea, Seoul, Korea.
  • Chung JB; Department of Radiation Oncology, Seoul National University Bundang Hospital, Seongnam, Korea.
  • Suh TS; Department of Biomedicine & Health Sciences, Research Institute of Biomedical Engineering, College of Medicine, the Catholic University of Korea, Seoul, Korea.
  • Kang SW; Department of Biomedicine & Health Sciences, Research Institute of Biomedical Engineering, College of Medicine, the Catholic University of Korea, Seoul, Korea.
  • Kang SH; Department of Radiation Oncology, Seoul National University Bundang Hospital, Seongnam, Korea.
  • Eom KY; Department of Radiation Oncology, Seoul National University Bundang Hospital, Seongnam, Korea.
  • Song C; Department of Radiation Oncology, Seoul National University Bundang Hospital, Seongnam, Korea.
  • Kim IA; Department of Radiation Oncology, Seoul National University Bundang Hospital, Seongnam, Korea.
  • Kim JS; Department of Radiation Oncology, Seoul National University Bundang Hospital, Seongnam, Korea.
PLoS One ; 13(11): e0207232, 2018.
Article en En | MEDLINE | ID: mdl-30419058
To investigate feasible treatment planning parameters, we aimed to evaluate the dosimetric and radiobiological impact of the dose calculation algorithm and grid size in the volumetric modulated arc therapy (VMAT) plan for prostate cancer. Twenty patients were selected, and the treatment plans were initially generated with anisotropic analytical algorithm (AAA) and recalculated with Acuros XB (AXB) algorithm. Various dose grids were used for AXB (1, 2, and 3 mm) and AAA (1, 3, and 5 mm) plan. Dosimetric parameters such as homogeneity index (HI) and conformity index (CI), and radiobiological parameters such as tumor control probability (TCP) and normal tissue complication probability (NTCP) were calculated. Significant differences were observed in the planning target volume (PTV) coverage between both algorithms, and the V95%, HI, and CI of AAA were significantly affected by grid (p < 0.01). On 1 mm grid, the mean rectal dose difference between both algorithms was 2.87% of the prescription dose (p < 0.01), which was the highest among the critical organs. The TCP and NTCP of the AAA were higher than those of AXB (p < 0.01). Compared to AXB with 1 mm grid, the 2 mm grid showed comparable dose calculation accuracy with short calculation time. This study found that the PTV and rectum show significant differences according to dose calculation algorithm and grid. Considering the dose calculation performance for heterogeneous area, we recommend AXB with 2 mm grid for improving treatment efficiency of prostate VMAT.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Próstata / Algoritmos / Planificación de la Radioterapia Asistida por Computador / Radioterapia de Intensidad Modulada Tipo de estudio: Evaluation_studies / Observational_studies / Prognostic_studies Límite: Aged / Aged80 / Humans / Male / Middle aged Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Próstata / Algoritmos / Planificación de la Radioterapia Asistida por Computador / Radioterapia de Intensidad Modulada Tipo de estudio: Evaluation_studies / Observational_studies / Prognostic_studies Límite: Aged / Aged80 / Humans / Male / Middle aged Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos