Your browser doesn't support javascript.
loading
Evaluation of Inhibitory Activities of UK-2A, an Antimycin-Type Antibiotic, and Its Synthetic Analogues against the Production of Anti-inflammatory Cytokine IL-4.
Usuki, Yoshinosuke; Ishii, Saho; Ijiri, Minako; Yoshida, Ken-Ichi; Satoh, Tetsuya; Horigome, Satoru; Yoshida, Izumi; Mishima, Takashi; Fujita, Ken-Ichi.
Afiliación
  • Usuki Y; Department of Chemistry, Graduate School of Science , Osaka City University , 3-3-138 Sugimoto , Sumiyoshi, Osaka 558-8585 , Japan.
  • Ishii S; Department of Chemistry, Graduate School of Science , Osaka City University , 3-3-138 Sugimoto , Sumiyoshi, Osaka 558-8585 , Japan.
  • Ijiri M; Department of Chemistry, Graduate School of Science , Osaka City University , 3-3-138 Sugimoto , Sumiyoshi, Osaka 558-8585 , Japan.
  • Yoshida KI; Department of Chemistry, Graduate School of Science , Osaka City University , 3-3-138 Sugimoto , Sumiyoshi, Osaka 558-8585 , Japan.
  • Satoh T; Department of Chemistry, Graduate School of Science , Osaka City University , 3-3-138 Sugimoto , Sumiyoshi, Osaka 558-8585 , Japan.
  • Horigome S; Saito Laboratory , Japan Food Research Laboratories , 4-41 Saito-asagi 7-chome , Ibaraki-shi, Osaka 567-0085 , Japan.
  • Yoshida I; Saito Laboratory , Japan Food Research Laboratories , 4-41 Saito-asagi 7-chome , Ibaraki-shi, Osaka 567-0085 , Japan.
  • Mishima T; Saito Laboratory , Japan Food Research Laboratories , 4-41 Saito-asagi 7-chome , Ibaraki-shi, Osaka 567-0085 , Japan.
  • Fujita KI; Department of Biology, Graduate School of Science , Osaka City University , 3-3-138 Sugimoto , Sumiyoshi, Osaka 558-8585 , Japan.
J Nat Prod ; 81(11): 2590-2594, 2018 11 26.
Article en En | MEDLINE | ID: mdl-30417645
The inhibitory activities of the antimycin-class antibiotics UK-2A, antimycin A, and splenocin B against the production of anti-inflammatory cytokine IL-4, which is related to IgE-mediated allergic responses in rat basophilic leukemia (RBL-2H3) cells, were evaluated. Although antimycin A and splenocin B showed cytotoxicity at concentrations at which IL-4 release from the cells was restricted, UK-2A was found to restrict IL-4 release without cytotoxicity. Three UK-2A analogues (4-6) were then synthesized and assessed. Compound 5 restricted IL-4 release dose-dependently without cytotoxicity, and its effect was more potent than that of UK-2A.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Interleucina-4 / Mediadores de Inflamación / Antibacterianos Límite: Animals Idioma: En Revista: J Nat Prod Año: 2018 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Interleucina-4 / Mediadores de Inflamación / Antibacterianos Límite: Animals Idioma: En Revista: J Nat Prod Año: 2018 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos