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Quantification of Calcyclin and Heat Shock Protein 90 in Sera from Women with and without Preeclampsia by Mass Spectrometry.
Güzel, Coskun; van den Berg, Caroline B; Duvekot, Johannes J; Stingl, Christoph; van den Bosch, Thierry P P; van der Weiden, Marcel; Steegers, Eric A P; Steegers-Theunissen, Regine P M; Luider, Theo M.
Afiliación
  • Güzel C; Laboratory of Neuro-Oncology/Clinical and Cancer Proteomics, Department of Neurology, Erasmus University Medical Center Rotterdam, 3015 CN, Rotterdam, The Netherlands.
  • van den Berg CB; Departments of Obstetrics and Gynecology, Erasmus University Medical Center Rotterdam, 3015 CN, Rotterdam, The Netherlands.
  • Duvekot JJ; Departments of Obstetrics and Gynecology, Erasmus University Medical Center Rotterdam, 3015 CN, Rotterdam, The Netherlands.
  • Stingl C; Laboratory of Neuro-Oncology/Clinical and Cancer Proteomics, Department of Neurology, Erasmus University Medical Center Rotterdam, 3015 CN, Rotterdam, The Netherlands.
  • van den Bosch TPP; Department of Pathology, Erasmus University Medical Center Rotterdam, 3015 CN, Rotterdam, The Netherlands.
  • van der Weiden M; Department of Pathology, Erasmus University Medical Center Rotterdam, 3015 CN, Rotterdam, The Netherlands.
  • Steegers EAP; Departments of Obstetrics and Gynecology, Erasmus University Medical Center Rotterdam, 3015 CN, Rotterdam, The Netherlands.
  • Steegers-Theunissen RPM; Departments of Obstetrics and Gynecology, Erasmus University Medical Center Rotterdam, 3015 CN, Rotterdam, The Netherlands.
  • Luider TM; Laboratory of Neuro-Oncology/Clinical and Cancer Proteomics, Department of Neurology, Erasmus University Medical Center Rotterdam, 3015 CN, Rotterdam, The Netherlands.
Proteomics Clin Appl ; 13(3): e1800181, 2019 05.
Article en En | MEDLINE | ID: mdl-30417587
PURPOSE: The objective of present study is to determine serum levels and placental distribution of two interacting proteins calcyclin and heat shock protein 90 in preeclampsia. EXPERIMENTAL DESIGN: Maternal serum levels of calcyclin and heat shock protein 90 are compared throughout pregnancy from the first trimester till term among women with preeclampsia (n = 43) and age-matched normotensive pregnant controls (n = 46). A serum-based 2D LC-MS assay using Parallel Reaction Monitoring is applied to quantify both calcyclin and heat shock protein 90. RESULTS: Serum levels of calcyclin are significantly lower in patients with preeclampsia in the second trimester of pregnancy as compared to controls (p < 0.05). Serum levels of heat shock protein 90 are significantly higher in patients with preeclampsia in the third trimester as compared to controls (p < 0.001). CONCLUSION AND CLINICAL RELEVANCE: Both interacting proteins calcyclin and heat shock protein 90 are notably changed in preeclamptic patients compared to controls. Calcyclin is already decreased before the onset of preeclampsia in the second trimester and HSP90 is strongly increased in the third trimester. This suggests that these proteins may play a role in the pathogenesis of preeclampsia and ought to be investigated in large cohort studies as molecular biomarkers.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Placenta / Preeclampsia / Proteínas HSP90 de Choque Térmico / Proteína A6 de Unión a Calcio de la Familia S100 Tipo de estudio: Observational_studies Límite: Adult / Female / Humans / Pregnancy Idioma: En Revista: Proteomics Clin Appl Asunto de la revista: BIOQUIMICA Año: 2019 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Placenta / Preeclampsia / Proteínas HSP90 de Choque Térmico / Proteína A6 de Unión a Calcio de la Familia S100 Tipo de estudio: Observational_studies Límite: Adult / Female / Humans / Pregnancy Idioma: En Revista: Proteomics Clin Appl Asunto de la revista: BIOQUIMICA Año: 2019 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Alemania