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Oxytocin receptor gene methylation in male and female PTSD patients and trauma-exposed controls.
Nawijn, L; Krzyzewska, I M; van Zuiden, M; Henneman, P; Koch, S B J; Mul, A N; Frijling, J L; Veltman, D J; Mannens, M M A M; Olff, M.
Afiliación
  • Nawijn L; Department of Psychiatry, Anxiety Disorders, Academic Medical Center, Amsterdam, the Netherlands; Department of Psychiatry, Amsterdam Neuroscience, Vrije Universiteit Medical Center, Amsterdam, the Netherlands. Electronic address: l.nawijn@vumc.nl.
  • Krzyzewska IM; Department of Clinical Genetics, Genome Diagnostics laboratory, Academic Medical Center, Amsterdam, the Netherlands.
  • van Zuiden M; Department of Psychiatry, Anxiety Disorders, Academic Medical Center, Amsterdam, the Netherlands.
  • Henneman P; Department of Clinical Genetics, Genome Diagnostics laboratory, Academic Medical Center, Amsterdam, the Netherlands.
  • Koch SBJ; Department of Psychiatry, Anxiety Disorders, Academic Medical Center, Amsterdam, the Netherlands; Donders Institute for Brain, Cognition and Behaviour, Centre for Cognitive Neuroimaging, Radboud University Nijmegen, the Netherlands.
  • Mul AN; Department of Clinical Genetics, Genome Diagnostics laboratory, Academic Medical Center, Amsterdam, the Netherlands.
  • Frijling JL; Department of Psychiatry, Anxiety Disorders, Academic Medical Center, Amsterdam, the Netherlands.
  • Veltman DJ; Department of Psychiatry, Amsterdam Neuroscience, Vrije Universiteit Medical Center, Amsterdam, the Netherlands.
  • Mannens MMAM; Department of Clinical Genetics, Genome Diagnostics laboratory, Academic Medical Center, Amsterdam, the Netherlands.
  • Olff M; Department of Psychiatry, Anxiety Disorders, Academic Medical Center, Amsterdam, the Netherlands; Arq Psychotrauma Expert Group, Diemen, the Netherlands.
Eur Neuropsychopharmacol ; 29(1): 147-155, 2019 01.
Article en En | MEDLINE | ID: mdl-30415783
Oxytocin receptor gene (OXTR) DNA-methylation levels have been associated with trauma-exposure, mood- and anxiety disorders, and social processes relevant to posttraumatic stress disorder (PTSD). We hypothesized that OXTR methylation may play a role in the neurobiological underpinnings of PTSD. In the current study, we compared OXTR methylation between PTSD patients (n = 31, 14 females) and trauma-exposed controls (n = 36, 19 females). Additionally, the association between OXTR methylation and PTSD symptom severity and amygdala reactivity to an emotional faces task was assessed, as a neural hallmark of PTSD. DNA-methylation was investigated in the CpG island located at exon 3 of the OXTR, previously associated with OXTR expression. We observed a significant interaction between PTSD-status, sex and CpG-position on methylation levels. Post-hoc testing revealed that methylation levels at two specific CpG-sites were significantly higher in PTSD females compared to female trauma-exposed controls and PTSD males (CpGs Chr3:8809437, Chr3:8809413). No significant differences in methylation were observed between male PTSD patients and controls. Furthermore, within PTSD females, methylation in these CpG-sites was positively associated with anhedonia symptoms and with left amygdala responses to negative emotional faces, although this was no longer significant after stringent correction for multiple-comparisons. Though the modest size of the current sample is an important limitation, we are the first to report on OXTR methylation in PTSD, replicating previously observed (sex-specific) associations of OXTR methylation with other psychiatric disorders.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastornos por Estrés Postraumático / Caracteres Sexuales / Receptores de Oxitocina / Metilación de ADN / Trauma Psicológico Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Female / Humans / Male Idioma: En Revista: Eur Neuropsychopharmacol Asunto de la revista: PSICOFARMACOLOGIA Año: 2019 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastornos por Estrés Postraumático / Caracteres Sexuales / Receptores de Oxitocina / Metilación de ADN / Trauma Psicológico Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Female / Humans / Male Idioma: En Revista: Eur Neuropsychopharmacol Asunto de la revista: PSICOFARMACOLOGIA Año: 2019 Tipo del documento: Article Pais de publicación: Países Bajos