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Correcting Cherenkov light attenuation in tissue using spatial frequency domain imaging for quantitative surface dosimetry during whole breast radiation therapy.
Hachadorian, Rachael; Bruza, Petr; Jermyn, Michael; Mazhar, Amaan; Cuccia, David; Jarvis, Lesley; Gladstone, David; Pogue, Brian.
Afiliación
  • Hachadorian R; Dartmouth College, Thayer School of Engineering, Hanover, New Hampshire, United States.
  • Bruza P; Dartmouth College, Thayer School of Engineering, Hanover, New Hampshire, United States.
  • Jermyn M; DoseOptics LLC, Lebanon, New Hampshire, United States.
  • Mazhar A; Modulated Imaging Inc., Irvine, California, United States.
  • Cuccia D; Modulated Imaging Inc., Irvine, California, United States.
  • Jarvis L; Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, United States.
  • Gladstone D; Norris Cotton Cancer Center, Lebanon, New Hampshire, United States.
  • Pogue B; Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, United States.
J Biomed Opt ; 24(7): 1-10, 2018 11.
Article en En | MEDLINE | ID: mdl-30415511
Imaging Cherenkov emission during radiotherapy permits real-time visualization of external beam delivery on superficial tissue. This signal is linear with absorbed dose in homogeneous media, indicating potential for quantitative dosimetry. In humans, the inherent heterogeneity of tissue optical properties (primarily from blood and skin pigment) distorts the linearity between detected Cherenkov signal and absorbed dose. We examine the potential to correct for superficial vasculature using spatial frequency domain imaging (SFDI) to map tissue optical properties for large fields of view. In phantoms, applying intensity corrections to simulate blood vessels improves Cherenkov image (CI) negative contrast by 24% for a vessel 1.9-mm-in diameter. In human trials, SFDI and CI are acquired for women undergoing whole breast radiotherapy. Applied corrections reduce heterogeneity due to vasculature within the sampling limits of the SFDI from a 22% difference as compared to the treatment plan, down to 6% in one region and from 14% down to 4% in another region. The optimal use for this combined imaging system approach is to correct for small heterogeneities such as superficial blood vessels or for interpatient variations in blood/melanin content such that the corrected CI more closely represents the surface dose delivered.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Radiometría / Procesamiento de Señales Asistido por Computador / Neoplasias de la Mama / Interpretación de Imagen Asistida por Computador Límite: Female / Humans Idioma: En Revista: J Biomed Opt Asunto de la revista: ENGENHARIA BIOMEDICA / OFTALMOLOGIA Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Radiometría / Procesamiento de Señales Asistido por Computador / Neoplasias de la Mama / Interpretación de Imagen Asistida por Computador Límite: Female / Humans Idioma: En Revista: J Biomed Opt Asunto de la revista: ENGENHARIA BIOMEDICA / OFTALMOLOGIA Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos