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Recruitment of CCR6+  Foxp3+ regulatory gastric infiltrating lymphocytes in Helicobacter pylori gastritis.
Wu, Yi-Ying; Hsieh, Chin-Tung; Tsay, Gregory J; Kao, Jung-Ta; Chiu, Ying-Ming; Shieh, Dong-Chen; Lee, Yi-Ju.
Afiliación
  • Wu YY; Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung, Taiwan.
  • Hsieh CT; Chinese Medicine Research Center, China Medical University, Taichung, Taiwan.
  • Tsay GJ; Research Center for Chinese Herbal Medicine, China Medical University, Taichung, Taiwan.
  • Kao JT; Department of Pediatrics, Lotung Poh-Ai Hospital, I-Lan, Taiwan.
  • Chiu YM; Division of Immunology and Rheumatology, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan.
  • Shieh DC; Department of Internal Medicine, School of Medicine, China Medical University Hospital, China Medical University, Taichung, Taiwan.
  • Lee YJ; Department of Internal Medicine, School of Medicine, China Medical University Hospital, China Medical University, Taichung, Taiwan.
Helicobacter ; 24(1): e12550, 2019 Feb.
Article en En | MEDLINE | ID: mdl-30412323
Helicobacter pylori (H. pylori) infection is associated with an inflammatory response in the gastric mucosa, leading to chronic gastritis, peptic ulcers, and gastric cancer. Increased T-cell infiltration is found at sites of H. pylori infection. The CCR6+ subset of CD4+ regulatory T cells (Tregs), a newly characterized subset of Tregs, has been reported to contribute to local immune inhibition. However, whether CCR6+ Tregs are present in H. pylori gastritis, and what their relationship is to disease prognosis, remains to be elucidated. In this study, gastric infiltrating lymphocytes were isolated from endoscopic biopsy specimens of H. pylori gastritis patients and analyzed. We found that in gastric infiltrating lymphocytes, CCR6+  CD4+  CD25high Tregs, which express high levels of CD45RO, are positively associated with more severe inflammation in gastric mucosa during H. pylori infection. Furthermore, the frequency of CCR6+ Tregs in gastric infiltrating lymphocytes, but not CCR6- Tregs, is significantly increased in inflamed gastric tissues, which is inversely correlated with significantly lower expression of IFN-γ+  CD8+ T cells. We also found that the frequency of CCR6+ Tregs is positively correlated with the frequency of CD4+  IFN-γ+ T cells. In addition, the frequency of CCR6+ Tregs, but not that of CCR6- Tregs, is significantly correlated with increased inflammation in H. pylori gastritis. This study demonstrates that immunosuppression in H. pylori gastritis might be related to the activity of CCR6+ Tregs, which could influence disease prognosis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Helicobacter pylori / Infecciones por Helicobacter / Linfocitos T Reguladores / Factores de Transcripción Forkhead / Receptores CCR6 / Gastritis Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Helicobacter Asunto de la revista: BACTERIOLOGIA Año: 2019 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Helicobacter pylori / Infecciones por Helicobacter / Linfocitos T Reguladores / Factores de Transcripción Forkhead / Receptores CCR6 / Gastritis Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Helicobacter Asunto de la revista: BACTERIOLOGIA Año: 2019 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Reino Unido