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Obesity is Associated with Higher Blood Pressure and Higher Levels of Angiotensin II but Lower Angiotensin-(1-7) in Adolescents Born Preterm.
South, Andrew M; Nixon, Patricia A; Chappell, Mark C; Diz, Debra I; Russell, Gregory B; Shaltout, Hossam A; O'Shea, T Michael; Washburn, Lisa K.
Afiliación
  • South AM; Department of Pediatrics, Wake Forest School of Medicine, Winston Salem, NC; Cardiovascular Sciences Center, Wake Forest School of Medicine, Winston Salem, NC; Division of Public Health Sciences, Department of Epidemiology and Prevention, Wake Forest School of Medicine, Winston Salem, NC. Electronic
  • Nixon PA; Department of Pediatrics, Wake Forest School of Medicine, Winston Salem, NC; Department of Health and Exercise Science, Wake Forest University, Winston Salem, NC.
  • Chappell MC; Cardiovascular Sciences Center, Wake Forest School of Medicine, Winston Salem, NC; Department of Surgery-Hypertension and Vascular Research, Wake Forest School of Medicine, Winston Salem, NC.
  • Diz DI; Cardiovascular Sciences Center, Wake Forest School of Medicine, Winston Salem, NC; Department of Surgery-Hypertension and Vascular Research, Wake Forest School of Medicine, Winston Salem, NC.
  • Russell GB; Division of Public Health Sciences, Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston Salem, NC.
  • Shaltout HA; Cardiovascular Sciences Center, Wake Forest School of Medicine, Winston Salem, NC; Department of Obstetrics and Gynecology, Wake Forest School of Medicine, Winston Salem, NC; Department of Pharmacology and Toxicology, School of Pharmacy, University of Alexandria, Alexandria, Egypt.
  • O'Shea TM; Department of Pediatrics, University of North Carolina School of Medicine, Chapel Hill, NC.
  • Washburn LK; Department of Pediatrics, Wake Forest School of Medicine, Winston Salem, NC; Cardiovascular Sciences Center, Wake Forest School of Medicine, Winston Salem, NC.
J Pediatr ; 205: 55-60.e1, 2019 02.
Article en En | MEDLINE | ID: mdl-30404738
OBJECTIVES: To evaluate if obesity is associated with increased angiotensin II (Ang II) and decreased angiotensin-(1-7) or Ang-(1-7) in the circulation and urine among adolescents born prematurely. STUDY DESIGN: In a cross-sectional analysis of 175 14-year-olds born preterm with very low birth weight, we quantified plasma and urinary Ang II and Ang-(1-7) and compared their levels between subjects with overweight/obesity (body mass index ≥85th percentile, n = 61) and those with body mass index <85th percentile (n = 114) using generalized linear models, adjusted for race and antenatal corticosteroid exposure. RESULTS: Overweight/obesity was associated with higher systolic blood pressure and a greater proportion with high blood pressure. After adjustment for confounders, overweight/obesity was associated with an elevated ratio of plasma Ang II to Ang-(1-7) (ß: 0.57, 95% CI 0.23-0.91) and higher Ang II (ß: 0.21 pmol/L, 95% CI 0.03-0.39) but lower Ang-(1-7) (ß: -0.37 pmol/L, 95% CI -0.7 to -0.04). Overweight/obesity was associated with a higher ratio of urinary Ang II to Ang-(1-7) (ß: 0.21, 95% CI -0.02 to 0.44), an effect that approached statistical significance. CONCLUSIONS: Among preterm-born adolescents, overweight/obesity was associated with increased Ang II but reduced Ang-(1-7) in the circulation and the kidney as well as higher blood pressure. Obesity may compound the increased risk of hypertension and cardiovascular disease in individuals born prematurely by further augmenting the prematurity-associated imbalance in the renin-angiotensin system.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Nacimiento Prematuro / Obesidad Infantil Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Adolescent / Female / Humans / Male / Newborn / Pregnancy Idioma: En Revista: J Pediatr Año: 2019 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Nacimiento Prematuro / Obesidad Infantil Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Adolescent / Female / Humans / Male / Newborn / Pregnancy Idioma: En Revista: J Pediatr Año: 2019 Tipo del documento: Article Pais de publicación: Estados Unidos