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Distinct White Matter Changes Associated with Cerebrospinal Fluid Amyloid-ß1-42 and Hypertension.
Al-Janabi, Omar M; Brown, Christopher A; Bahrani, Ahmed A; Abner, Erin L; Barber, Justin M; Gold, Brian T; Goldstein, Larry B; Murphy, Ronan R; Nelson, Peter T; Johnson, Nathan F; Shaw, Leslie M; Smith, Charles D; Trojanowski, John Q; Wilcock, Donna M; Jicha, Gregory A.
Afiliación
  • Al-Janabi OM; Sanders-Brown Center on Aging, University of Kentucky Colleges of Medicine, Public Health, Health Sciences and Engineering Lexington, KY, USA.
  • Brown CA; Departments of Behavioral Science, University of Kentucky Colleges of Medicine, Public Health, Health Sciences and Engineering Lexington, KY, USA.
  • Bahrani AA; Departments of Neuroscience, University of Kentucky Colleges of Medicine, Public Health, Health Sciences and Engineering Lexington, KY, USA.
  • Abner EL; Sanders-Brown Center on Aging, University of Kentucky Colleges of Medicine, Public Health, Health Sciences and Engineering Lexington, KY, USA.
  • Barber JM; Departments of Biomedical Engineering, University of Kentucky Colleges of Medicine, Public Health, Health Sciences and Engineering Lexington, KY, USA.
  • Gold BT; Sanders-Brown Center on Aging, University of Kentucky Colleges of Medicine, Public Health, Health Sciences and Engineering Lexington, KY, USA.
  • Goldstein LB; Departments of Epidemiology and Biostatistics, University of Kentucky Colleges of Medicine, Public Health, Health Sciences and Engineering Lexington, KY, USA.
  • Murphy RR; Sanders-Brown Center on Aging, University of Kentucky Colleges of Medicine, Public Health, Health Sciences and Engineering Lexington, KY, USA.
  • Nelson PT; Sanders-Brown Center on Aging, University of Kentucky Colleges of Medicine, Public Health, Health Sciences and Engineering Lexington, KY, USA.
  • Johnson NF; Departments of Neuroscience, University of Kentucky Colleges of Medicine, Public Health, Health Sciences and Engineering Lexington, KY, USA.
  • Shaw LM; Departments of Neurology, University of Kentucky Colleges of Medicine, Public Health, Health Sciences and Engineering Lexington, KY, USA.
  • Smith CD; Sanders-Brown Center on Aging, University of Kentucky Colleges of Medicine, Public Health, Health Sciences and Engineering Lexington, KY, USA.
  • Trojanowski JQ; Departments of Neurology, University of Kentucky Colleges of Medicine, Public Health, Health Sciences and Engineering Lexington, KY, USA.
  • Wilcock DM; Sanders-Brown Center on Aging, University of Kentucky Colleges of Medicine, Public Health, Health Sciences and Engineering Lexington, KY, USA.
  • Jicha GA; Departments of Pathology, University of Kentucky Colleges of Medicine, Public Health, Health Sciences and Engineering Lexington, KY, USA.
J Alzheimers Dis ; 66(3): 1095-1104, 2018.
Article en En | MEDLINE | ID: mdl-30400099
BACKGROUND: Alzheimer's disease (AD) pathology and hypertension (HTN) are risk factors for development of white matter (WM) alterations and might be independently associated with these alterations in older adults. OBJECTIVE: To evaluate the independent and synergistic effects of HTN and AD pathology on WM alterations. METHODS: Clinical measures of cerebrovascular disease risk were collected from 62 participants in University of Kentucky Alzheimer's Disease Center studies who also had cerebrospinal fluid (CSF) sampling and MRI brain scans. CSF Aß1-42 levels were measured as a marker of AD, and fluid-attenuated inversion recovery imaging and diffusion tensor imaging were obtained to assess WM macro- and microstructural properties. Linear regression analyses were used to assess the relationships among WM alterations, cerebrovascular disease risk, and AD pathology. Voxelwise analyses were performed to examine spatial patterns of WM alteration associated with each pathology. RESULTS: HTN and CSF Aß1-42 levels were each associated with white matter hyperintensities (WMH). Also, CSF Aß1-42 levels were associated with alterations in normal appearing white matter fractional anisotropy (NAWM-FA), whereas HTN was marginally associated with alterations in NAWM-FA. Linear regression analyses demonstrated significant main effects of HTN and CSF Aß1-42 on WMH volume, but no significant HTN×CSF Aß1-42 interaction. Furthermore, voxelwise analyses showed unique patterns of WM alteration associated with hypertension and CSF Aß1-42. CONCLUSION: Associations of HTN and lower CSF Aß1-42 with WM alteration were statistically and spatially distinct, suggesting independent rather than synergistic effects. Considering such spatial distributions may improve diagnostic accuracy to address each underlying pathology.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fragmentos de Péptidos / Trastornos Cerebrovasculares / Péptidos beta-Amiloides / Enfermedad de Alzheimer / Sustancia Blanca / Hipertensión Tipo de estudio: Risk_factors_studies Límite: Aged / Aged80 / Female / Humans / Male Idioma: En Revista: J Alzheimers Dis Asunto de la revista: GERIATRIA / NEUROLOGIA Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fragmentos de Péptidos / Trastornos Cerebrovasculares / Péptidos beta-Amiloides / Enfermedad de Alzheimer / Sustancia Blanca / Hipertensión Tipo de estudio: Risk_factors_studies Límite: Aged / Aged80 / Female / Humans / Male Idioma: En Revista: J Alzheimers Dis Asunto de la revista: GERIATRIA / NEUROLOGIA Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Países Bajos