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An exploration of Prevotella-rich microbiomes in HIV and men who have sex with men.
Armstrong, Abigail J S; Shaffer, Michael; Nusbacher, Nichole M; Griesmer, Christine; Fiorillo, Suzanne; Schneider, Jennifer M; Preston Neff, C; Li, Sam X; Fontenot, Andrew P; Campbell, Thomas; Palmer, Brent E; Lozupone, Catherine A.
Afiliación
  • Armstrong AJS; Department of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA.
  • Shaffer M; Department of Immunology and Microbiology, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA.
  • Nusbacher NM; Department of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA.
  • Griesmer C; Computational Bioscience Program, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA.
  • Fiorillo S; Department of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA.
  • Schneider JM; Department of Surgery, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA.
  • Preston Neff C; Department of Surgery, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA.
  • Li SX; Department of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA.
  • Fontenot AP; Department of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA.
  • Campbell T; Department of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA.
  • Palmer BE; Department of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA.
  • Lozupone CA; Department of Surgery, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA.
Microbiome ; 6(1): 198, 2018 11 05.
Article en En | MEDLINE | ID: mdl-30396369
BACKGROUND: Gut microbiome characteristics associated with HIV infection are of intense research interest but a deep understanding has been challenged by confounding factors across studied populations. Notably, a Prevotella-rich microbiome described in HIV-infected populations is now understood to be common in men who have sex with men (MSM) regardless of HIV status, but driving factors and potential health implications are unknown. RESULTS: Here, we further define the MSM-associated gut microbiome and describe compositional differences between the fecal microbiomes of Prevotella-rich MSM and non-MSM that may underlie observed pro-inflammatory properties. Furthermore, we show relatively subtle gut microbiome changes in HIV infection in MSM and women that include an increase in potential pathogens that is ameliorated with antiretroviral therapy (ART). Lastly, using a longitudinal cohort, we describe microbiome changes that happen after ART initiation. CONCLUSIONS: This study provides an in-depth characterization of microbiome differences that occur in a US population infected with HIV and demonstrates the degree to which these differences may be driven by lifestyle factors, ART, and HIV infection itself. Understanding microbiome compositions that occur with sexual behaviors that are high risk for acquiring HIV and untreated and ART-treated HIV infection will guide the investigation of immune and metabolic functional implications to ultimately target the microbiome therapeutically.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones por VIH / Prevotella / Antirretrovirales / Microbioma Gastrointestinal / Minorías Sexuales y de Género Tipo de estudio: Etiology_studies / Observational_studies / Qualitative_research / Risk_factors_studies Límite: Female / Humans / Male Idioma: En Revista: Microbiome Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones por VIH / Prevotella / Antirretrovirales / Microbioma Gastrointestinal / Minorías Sexuales y de Género Tipo de estudio: Etiology_studies / Observational_studies / Qualitative_research / Risk_factors_studies Límite: Female / Humans / Male Idioma: En Revista: Microbiome Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido