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Lipophilic Permeability Efficiency Reconciles the Opposing Roles of Lipophilicity in Membrane Permeability and Aqueous Solubility.
Naylor, Matthew R; Ly, Andrew M; Handford, Mason J; Ramos, Daniel P; Pye, Cameron R; Furukawa, Akihiro; Klein, Victoria G; Noland, Ryan P; Edmondson, Quinn; Turmon, Alexandra C; Hewitt, William M; Schwochert, Joshua; Townsend, Chad E; Kelly, Colin N; Blanco, Maria-Jesus; Lokey, R Scott.
Afiliación
  • Naylor MR; Department of Chemistry and Biochemistry , University of California Santa Cruz , 1156 High Street , Santa Cruz , California 95064 , United States.
  • Ly AM; Department of Chemistry and Biochemistry , University of California Santa Cruz , 1156 High Street , Santa Cruz , California 95064 , United States.
  • Handford MJ; Department of Chemistry and Biochemistry , University of California Santa Cruz , 1156 High Street , Santa Cruz , California 95064 , United States.
  • Ramos DP; Department of Chemistry and Biochemistry , University of California Santa Cruz , 1156 High Street , Santa Cruz , California 95064 , United States.
  • Pye CR; Department of Chemistry and Biochemistry , University of California Santa Cruz , 1156 High Street , Santa Cruz , California 95064 , United States.
  • Furukawa A; Modality Research Laboratories , Daiichi Sankyo Company, Ltd. , 1-2-58 Hiromachi , Shingawa-ku, Tokyo 140-8710 , Japan.
  • Klein VG; Department of Chemistry and Biochemistry , University of California Santa Cruz , 1156 High Street , Santa Cruz , California 95064 , United States.
  • Noland RP; Department of Chemistry and Biochemistry , University of California Santa Cruz , 1156 High Street , Santa Cruz , California 95064 , United States.
  • Edmondson Q; Department of Chemistry and Biochemistry , University of California Santa Cruz , 1156 High Street , Santa Cruz , California 95064 , United States.
  • Turmon AC; Department of Chemistry and Biochemistry , University of California Santa Cruz , 1156 High Street , Santa Cruz , California 95064 , United States.
  • Hewitt WM; Department of Chemistry and Biochemistry , University of California Santa Cruz , 1156 High Street , Santa Cruz , California 95064 , United States.
  • Schwochert J; Department of Chemistry and Biochemistry , University of California Santa Cruz , 1156 High Street , Santa Cruz , California 95064 , United States.
  • Townsend CE; Department of Chemistry and Biochemistry , University of California Santa Cruz , 1156 High Street , Santa Cruz , California 95064 , United States.
  • Kelly CN; Department of Chemistry and Biochemistry , University of California Santa Cruz , 1156 High Street , Santa Cruz , California 95064 , United States.
  • Blanco MJ; Sage Therapeutics , 215 First Street, Suite 220 , Cambridge , Massachusetts 02142 , United States.
  • Lokey RS; Department of Chemistry and Biochemistry , University of California Santa Cruz , 1156 High Street , Santa Cruz , California 95064 , United States.
J Med Chem ; 61(24): 11169-11182, 2018 12 27.
Article en En | MEDLINE | ID: mdl-30395703
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Relación Estructura-Actividad / Preparaciones Farmacéuticas / Permeabilidad de la Membrana Celular Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Relación Estructura-Actividad / Preparaciones Farmacéuticas / Permeabilidad de la Membrana Celular Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos