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Effect of preoperative biliary drainage on cholestasis-associated inflammatory and fibrotic gene signatures in perihilar cholangiocarcinoma.
Reiniers, M J; de Haan, L; Weijer, R; Wiggers, J K; Jongejan, A; Moerland, P D; Alles, L K; van Kampen, A H C; van Gulik, T M; Heger, M; van Golen, R F.
Afiliación
  • Reiniers MJ; Department of Experimental Surgery, University of Amsterdam, Amsterdam, The Netherlands.
  • de Haan L; Department of Experimental Surgery, University of Amsterdam, Amsterdam, The Netherlands.
  • Weijer R; Department of Experimental Surgery, University of Amsterdam, Amsterdam, The Netherlands.
  • Wiggers JK; Department of Experimental Surgery, University of Amsterdam, Amsterdam, The Netherlands.
  • Jongejan A; Bioinformatics Laboratory, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands.
  • Moerland PD; Bioinformatics Laboratory, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands.
  • Alles LK; Department of Experimental Surgery, University of Amsterdam, Amsterdam, The Netherlands.
  • van Kampen AHC; Bioinformatics Laboratory, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands.
  • van Gulik TM; Department of Experimental Surgery, University of Amsterdam, Amsterdam, The Netherlands.
  • Heger M; Department of Experimental Surgery, University of Amsterdam, Amsterdam, The Netherlands.
  • van Golen RF; Department of Experimental Surgery, University of Amsterdam, Amsterdam, The Netherlands.
Br J Surg ; 106(1): 55-58, 2019 01.
Article en En | MEDLINE | ID: mdl-30395349
Preoperative biliary drainage (PBD) is used routinely in the evaluation of patients with potentially resectable perihilar cholangiocarcinoma to relieve cholestasis and improve the liver's resilience to surgery. Little preclinical or translatational data are, however, currently available to guide the use of PBD in this patient group. The effect of PBD on hepatic gene expression profiles was therefore studied by microarray analysis. Drainage affects inflammatory and fibrotic gene signatures.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de los Conductos Biliares / Expresión Génica / Drenaje / Colestasis / Tumor de Klatskin Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Female / Humans / Male / Middle aged Idioma: En Revista: Br J Surg Año: 2019 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Reino Unido
Texto completo
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Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de los Conductos Biliares / Expresión Génica / Drenaje / Colestasis / Tumor de Klatskin Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Female / Humans / Male / Middle aged Idioma: En Revista: Br J Surg Año: 2019 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Reino Unido