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International survey on anticoagulation and antiplatelet strategies after pediatric liver transplantation.
Calinescu, Ana M; Karam, Oliver; Wilde, Jim C H; Ansari, Marc; McLin, Valerie A; Wildhaber, Barbara E.
Afiliación
  • Calinescu AM; Division of Pediatric Surgery, University Center of Pediatric Surgery of Western Switzerland, Geneva University Hospitals, Geneva, Switzerland.
  • Karam O; Pediatric Intensive Care Unit, Geneva University Hospitals, Geneva, Switzerland.
  • Wilde JCH; Division of Pediatric Intensive Care Medicine, Children's Hospital of Richmond at VCU, Richmond, Virginia.
  • Ansari M; Division of Pediatric Surgery, University Center of Pediatric Surgery of Western Switzerland, Geneva University Hospitals, Geneva, Switzerland.
  • McLin VA; Division of Pediatrics, Unit of Pediatric Hematology, Geneva University Hospitals, Geneva, Switzerland.
  • Wildhaber BE; Division of Pediatric Specialties, Unit of Pediatric Gastroenterology, Hepatology and Nutrition, Geneva University Hospitals, Geneva, Switzerland.
Pediatr Transplant ; 23(1): e13317, 2019 02.
Article en En | MEDLINE | ID: mdl-30393923
In pediatric LT, anticoagulants and antiplatelet agents are regularly used to reduce the risk of vascular thrombosis. As evidence for optimal strategy is lacking, local practices vary greatly. The present survey aimed to compile an international overview of anticoagulation and antiplatelet strategies in pediatric LT. An online survey was sent to 98 pediatric LT centers in North and South America, Europe, Asia, and Australia. Twenty-four centers answered the survey. 20/24 (83%) use some sort of anticoagulation and antiplatelet therapy, yielding 20 different strategies. Perioperative vascular problems, size of the hepatic artery, and patient weight were the most frequent determinants of changes in anticoagulant and antiplatelet strategy. Early HAT rates were reported to be 5% or less in 79% of responding centers. Anticoagulation and antiplatelet strategies were not significantly associated with early HAT rates (P = 0.63), or with the number of pediatric LTs performed per year and center (P = 0.92). Internationally, there is a wide variety in anticoagulation and antiplatelet strategies after pediatric LT. Efforts must be made to design a prospective multicentric trial to identify the optimal antithrombotic strategy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Complicaciones Posoperatorias / Trombosis / Pautas de la Práctica en Medicina / Inhibidores de Agregación Plaquetaria / Trasplante de Hígado / Arteria Hepática / Anticoagulantes Tipo de estudio: Etiology_studies Límite: Child / Humans Idioma: En Revista: Pediatr Transplant Asunto de la revista: PEDIATRIA / TRANSPLANTE Año: 2019 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Dinamarca
Texto completo
Añadir a Mi BVS
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Complicaciones Posoperatorias / Trombosis / Pautas de la Práctica en Medicina / Inhibidores de Agregación Plaquetaria / Trasplante de Hígado / Arteria Hepática / Anticoagulantes Tipo de estudio: Etiology_studies Límite: Child / Humans Idioma: En Revista: Pediatr Transplant Asunto de la revista: PEDIATRIA / TRANSPLANTE Año: 2019 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Dinamarca