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Relations of combat stress and posttraumatic stress disorder to 24-h plasma and cerebrospinal fluid interleukin-6 levels and circadian rhythmicity.
Agorastos, Agorastos; Hauger, Richard L; Barkauskas, Donald A; Lerman, Imanuel R; Moeller-Bertram, Tobias; Snijders, Clara; Haji, Uzair; Patel, Piyush M; Geracioti, Thomas D; Chrousos, George P; Baker, Dewleen G.
Afiliación
  • Agorastos A; VA Center of Excellence for Stress and Mental Health, San Diego, CA, USA; Department of Psychiatry, Division of Neurosciences, School of Medicine, Faculty of Medical Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece.
  • Hauger RL; VA Center of Excellence for Stress and Mental Health, San Diego, CA, USA; VA San Diego Healthcare System, San Diego, CA, USA; Department of Psychiatry, University of California, San Diego (UCSD), CA, USA.
  • Barkauskas DA; Department of Preventive Medicine, Keck School of Medicine, University of Southern California (USC), Los Angeles, CA, USA.
  • Lerman IR; VA Center of Excellence for Stress and Mental Health, San Diego, CA, USA; Department of Anesthesiology, University of California, San Diego, San Diego, CA, USA.
  • Moeller-Bertram T; VA San Diego Healthcare System, San Diego, CA, USA; Department of Anesthesiology, University of California, San Diego, San Diego, CA, USA.
  • Snijders C; School for Mental Health and Neuroscience (MHeNS), Department of Psychiatry and Neuropsychology, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, the Netherlands.
  • Haji U; VA San Diego Healthcare System, San Diego, CA, USA.
  • Patel PM; VA San Diego Healthcare System, San Diego, CA, USA; Department of Anesthesiology, University of California, San Diego, San Diego, CA, USA.
  • Geracioti TD; University of Cincinnati Medical Center, Department of Psychiatry and Neurobehavioral Sciences, Cincinnati, OH, USA.
  • Chrousos GP; First Department of Pediatrics, School of Medicine, National and Kapodistrian University of Athens, "Aghia Sophia" Children's Hospital, Athens, Greece.
  • Baker DG; VA Center of Excellence for Stress and Mental Health, San Diego, CA, USA; VA San Diego Healthcare System, San Diego, CA, USA; Department of Psychiatry, University of California, San Diego (UCSD), CA, USA. Electronic address: dgbaker@ucsd.edu.
Psychoneuroendocrinology ; 100: 237-245, 2019 02.
Article en En | MEDLINE | ID: mdl-30390522
BACKGROUND: Acute and chronic stress can lead to a dysregulation of the immune response. Growing evidence suggests peripheral immune dysregulation and low-grade systemic inflammation in posttraumatic stress disorder (PTSD), with numerous reports of elevated plasma interleukin-6 (IL-6) levels. However, only a few studies have assessed IL-6 levels in the cerebrospinal fluid (CSF). Most of those have used single time-point measurements, and thus cannot take circadian level variability and CSF-plasma IL-6 correlations into account. METHODS: This study used time-matched, sequential 24-h plasma and CSF measurements to investigate the effects of combat stress and PTSD on physiologic levels and biorhythmicity of IL-6 in 35 male study volunteers, divided in 3 groups: (PTSD = 12, combat controls, CC = 12, and non-deployed healthy controls, HC = 11). RESULTS: Our findings show no differences in diurnal mean concentrations of plasma and CSF IL-6 across the three comparison groups. However, a significantly blunted circadian rhythm of plasma IL-6 across 24 h was observed in all combat-zone deployed participants, with or without PTSD, in comparison to HC. CSF IL-6 rhythmicity was unaffected by combat deployment or PTSD. CONCLUSIONS: Although no significant group differences in mean IL-6 concentration in either CSF or plasma over a 24-h timeframe was observed, we provide first evidence for a disrupted peripheral IL-6 circadian rhythm as a sequel of combat deployment, with this disruption occurring in both PTSD and CC groups. The plasma IL-6 circadian blunting remains to be replicated and its cause elucidated in future research.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastornos por Estrés Postraumático / Interleucina-6 / Ritmo Circadiano / Trastornos de Combate Tipo de estudio: Observational_studies Límite: Adult / Humans / Male Idioma: En Revista: Psychoneuroendocrinology Año: 2019 Tipo del documento: Article País de afiliación: Grecia Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastornos por Estrés Postraumático / Interleucina-6 / Ritmo Circadiano / Trastornos de Combate Tipo de estudio: Observational_studies Límite: Adult / Humans / Male Idioma: En Revista: Psychoneuroendocrinology Año: 2019 Tipo del documento: Article País de afiliación: Grecia Pais de publicación: Reino Unido