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Natural joints: Boundary lubrication and antiphospholipid syndrome (APS).
Pawlak, Zenon; Mrela, Aleksandra; Kaczmarek, Mariusz; Cieszko, Mieczyslaw; Urbaniak, Wieslaw.
Afiliación
  • Pawlak Z; Tribochemistry Consulting, Salt Lake City, UT 84117, USA; University of Economy, Biotribology Lab., Garbary 2, 85-229, Bydgoszcz, Poland. Electronic address: zpawlak@xmission.com.
  • Mrela A; Kujawy and Pomorze University in Bydgoszcz, Faculty of Technology, Torunska 55-57, Bydgoszcz, 85-023, Poland.
  • Kaczmarek M; Faculty of Mathematics, Physics and Technical Sciences, Kazimierz Wielki University, Chodkiewicza 30, 85-867, Bydgoszcz, Poland.
  • Cieszko M; Faculty of Mathematics, Physics and Technical Sciences, Kazimierz Wielki University, Chodkiewicza 30, 85-867, Bydgoszcz, Poland.
  • Urbaniak W; Faculty of Mathematics, Physics and Technical Sciences, Kazimierz Wielki University, Chodkiewicza 30, 85-867, Bydgoszcz, Poland.
Biosystems ; 177: 44-47, 2019 Mar.
Article en En | MEDLINE | ID: mdl-30389556
The paper shows that osteoporosis (OA) changes the SF content and the lipid profile substantially. To estimate the implication of the lipid environment in case the articular cartilage (AC) changes, we measured friction coefficient normal samples, with early and late stages of (OA). During joint inflammation and osteoarthritis, enzymatically activated ß2-Glycoprotein I is transformed into antibody conformation. Our hypothesis about cartilage degradation of PL bilayers by antibodies (ß2-Glycoprotein I) is considering antiphospholipid syndrome (APS), which was not discussed in the literature before. Deactivated PL molecule has no ability to form bilayers, lamellar phases, and liposomes. The phospholipid content in synovial fluid (SF) during joint inflammation, osteoarthritis, and rheumatoid arthritis is significantly higher (2-3 times) above the normal concentration of PL, and has a poor boundary-lubricating ability is deactivated.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Artritis / Líquido Sinovial / Cartílago Articular / Síndrome Antifosfolípido / Articulación de la Rodilla / Lípidos Tipo de estudio: Observational_studies Límite: Animals / Humans Idioma: En Revista: Biosystems Año: 2019 Tipo del documento: Article Pais de publicación: Irlanda
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Artritis / Líquido Sinovial / Cartílago Articular / Síndrome Antifosfolípido / Articulación de la Rodilla / Lípidos Tipo de estudio: Observational_studies Límite: Animals / Humans Idioma: En Revista: Biosystems Año: 2019 Tipo del documento: Article Pais de publicación: Irlanda