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Are hypothyroidism and hypogonadism clinically relevant in patients with malignant gliomas? A longitudinal trial in patients with glioma.
Handisurya, Ammon; Rumpold, Tamara; Caucig-Lütgendorf, Carola; Flechl, Birgit; Preusser, Matthias; Ilhan-Mutlu, Aysegül; Dieckmann, Karin; Widhalm, Georg; Grisold, Anna; Wöhrer, Adelheid; Hainfellner, Johannes; Ristl, Robin; Kurz, Christine; Marosi, Christine; Gessl, Alois; Hassler, Marco.
Afiliación
  • Handisurya A; Department of Medicine III, Division of Nephrology and Dialysis, Medical University of Vienna, Austria.
  • Rumpold T; Department of Radiation Oncology, Comprehensive Cancer Center, Medical University of Vienna, Austria.
  • Caucig-Lütgendorf C; MedAustron Ion Therapy Center, Wiener Neustadt, Austria.
  • Flechl B; MedAustron Ion Therapy Center, Wiener Neustadt, Austria; Institute of Radiooncology, Kaiser Franz-Josef Spital SMZ-Süd, Vienna, Austria.
  • Preusser M; Department of Medicine I, Division of Oncology, Comprehensive Cancer Center, Medical University of Vienna, Austria.
  • Ilhan-Mutlu A; Department of Medicine I, Division of Oncology, Comprehensive Cancer Center, Medical University of Vienna, Austria.
  • Dieckmann K; Department of Radiation Oncology, Comprehensive Cancer Center, Medical University of Vienna, Austria.
  • Widhalm G; Department of Neurosurgery, Medical University of Vienna, Austria.
  • Grisold A; Department of Neurology, Medical University of Vienna, Austria.
  • Wöhrer A; Institute of Neurology, Medical University of Vienna, Austria.
  • Hainfellner J; Institute of Neurology, Medical University of Vienna, Austria.
  • Ristl R; Center for Medical Statistics, Informatics and Intelligent Systems, Medical University of Vienna, Austria.
  • Kurz C; Department of Department of Obstetrics and Gynecology, Medical University of Vienna, Austria.
  • Marosi C; Department of Medicine I, Division of Oncology, Comprehensive Cancer Center, Medical University of Vienna, Austria. Electronic address: christine.marosi@meduniwien.ac.at.
  • Gessl A; Department of Medicine III, Division of Endocrinology and Metabolism, Medical University of Vienna, Austria.
  • Hassler M; Department of Medicine I, Division of Oncology, Comprehensive Cancer Center, Medical University of Vienna, Austria.
Radiother Oncol ; 130: 139-148, 2019 01.
Article en En | MEDLINE | ID: mdl-30389240
BACKGROUND: So far, the development and course of therapy-induced deficiencies in hypothalamic-pituitary hormones in adult patients with malignant gliomas has not received much attention. However, such deficiencies may impact patient's quality of life substantially. METHODS: In this monocentric longitudinal trial, we examined hormonal levels of TSH, T3, T4, fT3, fT4, FSH, LH, testosterone, estradiol and prolactin in patients with malignant high grade gliomas before the start of radiochemotherapy (RCT), at the end of RCT and then every three months for newly diagnosed patients and every six months in patients diagnosed more than two years before study inclusion. Growth hormone was not measured in this trial. RESULTS: 436 patients (198 female, 238 male) with high-grade gliomas, aged 19-83 years (median 50 years), were included in this study. Low levels of thyroid hormones were observed in around 10% of patients within the first six months of follow up and increasingly after 36 months. Half of premenopausal women at study entry developed premature menopause, 35% showed hyperprolactinemia. Low testosterone levels were measured in 37% of men aged less than 50 years and in 35/63 (55%) of men aged 50 years or older. DISCUSSION: The results of this study show that a significant percentage of patients with malignant gliomas develop hormonal deficiencies mandating regular clinical follow up, state of the art counseling and if clinically necessary substitution therapy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Encefálicas / Quimioradioterapia / Glioma / Hipogonadismo / Hipotiroidismo Tipo de estudio: Observational_studies Aspecto: Patient_preference Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Radiother Oncol Año: 2019 Tipo del documento: Article País de afiliación: Austria Pais de publicación: Irlanda
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Encefálicas / Quimioradioterapia / Glioma / Hipogonadismo / Hipotiroidismo Tipo de estudio: Observational_studies Aspecto: Patient_preference Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Radiother Oncol Año: 2019 Tipo del documento: Article País de afiliación: Austria Pais de publicación: Irlanda