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PPM1D Mutations Drive Clonal Hematopoiesis in Response to Cytotoxic Chemotherapy.
Hsu, Joanne I; Dayaram, Tajhal; Tovy, Ayala; De Braekeleer, Etienne; Jeong, Mira; Wang, Feng; Zhang, Jianhua; Heffernan, Timothy P; Gera, Sonal; Kovacs, Jeffrey J; Marszalek, Joseph R; Bristow, Christopher; Yan, Yuanqing; Garcia-Manero, Guillermo; Kantarjian, Hagop; Vassiliou, George; Futreal, P Andrew; Donehower, Lawrence A; Takahashi, Koichi; Goodell, Margaret A.
Afiliación
  • Hsu JI; Translational Biology and Molecular Medicine Graduate Program and Medical Scientist Training Program, Baylor College of Medicine, Houston, TX 77030, USA; Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX 77030, USA.
  • Dayaram T; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA.
  • Tovy A; Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX 77030, USA.
  • De Braekeleer E; Haematological Cancer Genetics, Wellcome Sanger Institute, Hinxton, Cambridge CB10 1SA, UK; Wellcome-MRC Stem Cell Institute, Cambridge Biomedical Campus, University of Cambridge, Cambridge CB2 0XY, UK.
  • Jeong M; Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX 77030, USA.
  • Wang F; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Zhang J; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Heffernan TP; Center for Co-Clinical Trials, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Gera S; Center for Co-Clinical Trials, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Kovacs JJ; Center for Co-Clinical Trials, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Marszalek JR; Center for Co-Clinical Trials, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Bristow C; Center for Co-Clinical Trials, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Yan Y; Department of Neurosurgery, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
  • Garcia-Manero G; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Kantarjian H; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Vassiliou G; Haematological Cancer Genetics, Wellcome Sanger Institute, Hinxton, Cambridge CB10 1SA, UK; Wellcome-MRC Stem Cell Institute, Cambridge Biomedical Campus, University of Cambridge, Cambridge CB2 0XY, UK.
  • Futreal PA; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Donehower LA; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA.
  • Takahashi K; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address: ktakahashi@mdanderson.org.
  • Goodell MA; Department of Pediatrics, Section of Hematology Oncology, Baylor College of Medicine, Houston, TX 77030, USA; Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address: goodell@bcm.edu.
Cell Stem Cell ; 23(5): 700-713.e6, 2018 11 01.
Article en En | MEDLINE | ID: mdl-30388424
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Leucemia Mieloide Aguda / Doxorrubicina / Cisplatino / Células Clonales / Proteína Fosfatasa 2C / Hematopoyesis / Mutación / Antineoplásicos Límite: Aged / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Cell Stem Cell Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Leucemia Mieloide Aguda / Doxorrubicina / Cisplatino / Células Clonales / Proteína Fosfatasa 2C / Hematopoyesis / Mutación / Antineoplásicos Límite: Aged / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Cell Stem Cell Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos