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Expanded teased nerve fibre pathological conditions in disease association.
Xu, Min; Pinto, Marcus; Sun, Chenjing; Engelstad, Janean K; James Dyck, P; Dyck, Peter J; Klein, Christopher J.
Afiliación
  • Xu M; Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
  • Pinto M; Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing, China.
  • Sun C; Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
  • Engelstad JK; Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
  • James Dyck P; Navy Teaching Hospital, Beijing, China.
  • Dyck PJ; Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
  • Klein CJ; Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
J Neurol Neurosurg Psychiatry ; 90(2): 138-140, 2019 02.
Article en En | MEDLINE | ID: mdl-30385486
OBJECTIVE: To describe an expanded teased nerve fibre classification in disease association. METHODS: We reviewed four newly proposed teased nerve fibre types (Types J-M): Type J, rope-like fibres; K, fibril-like clumps of osmium positivity; L, cellular debris along and within nerve fibres; M, circular axonal inclusions surrounded by thin myelin. Different clinical pathological entities were studied for these fibre types including chronic inflammatory demyelinating polyradiculoneuropathy (CIDP: N=20); amyloid polyneuropathy (N=20); intraneural B-cell lymphoma (N=20) or adult-onset polyglucosan body disease (APBD: N=6) in comparison with 112 disease controls. Student's t-test was used to test significance of association between the identified fibre types and the specific clinical diagnosis. RESULTS: Each fibre type significantly associated (p<0.001) with particular disease categories: Type J, 60% of CIDP cases; Type K, 75% of amyloid cases; Type L, 75% of intraneural lymphoma cases; Type M, 100% of APBD cases. Rarely were these fibres found in the other disease control cases ≤3% of cases. In three cases, the teased fibre findings were so striking additional paraffin nerve preparations were made to make the pathological diagnosis when initial paraffin sections were non-diagnostic. CONCLUSIONS: Teased nerve fibre Types J-M associate with commonly seen pathological diagnosis and are helpful in the consideration of specific neuropathy diagnoses.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad del Almacenamiento de Glucógeno / Linfoma de Células B / Neuropatías Amiloides / Polirradiculoneuropatía Crónica Inflamatoria Desmielinizante / Fibras Nerviosas / Enfermedades del Sistema Nervioso Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Neurol Neurosurg Psychiatry Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad del Almacenamiento de Glucógeno / Linfoma de Células B / Neuropatías Amiloides / Polirradiculoneuropatía Crónica Inflamatoria Desmielinizante / Fibras Nerviosas / Enfermedades del Sistema Nervioso Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Neurol Neurosurg Psychiatry Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido