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Mechanisms of synergistic neurotoxicity induced by two high risk pesticide residues - Chlorpyrifos and Carbofuran via oxidative stress.
Fu, Dong-Jun; Li, Ping; Song, Jian; Zhang, Sai-Yang; Xie, Han-Zhong.
Afiliación
  • Fu DJ; New Drug Research & Development Center, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China; Collaborative Innovation Center of New Drug Research and Safety Evaluation, Zhengzhou 450001, China; Key Laboratory of Technology of Drug Preparation, Zhengzhou University, M
  • Li P; New Drug Research & Development Center, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China; Collaborative Innovation Center of New Drug Research and Safety Evaluation, Zhengzhou 450001, China; Key Laboratory of Technology of Drug Preparation, Zhengzhou University, M
  • Song J; New Drug Research & Development Center, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China; Collaborative Innovation Center of New Drug Research and Safety Evaluation, Zhengzhou 450001, China; Key Laboratory of Technology of Drug Preparation, Zhengzhou University, M
  • Zhang SY; Zhengzhou Fruit Research Institute China Chinese Academy of Agricultural Sciences, Zhengzhou 450009, China; School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450001, China; New Drug Research & Development Center, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou
  • Xie HZ; Zhengzhou Fruit Research Institute China Chinese Academy of Agricultural Sciences, Zhengzhou 450009, China; Henan Key Laboratory of Fruit and Cucurbit Biology, Zhengzhou 450009, China. Electronic address: xiehanzhong@caas.cn.
Toxicol In Vitro ; 54: 338-344, 2019 Feb.
Article en En | MEDLINE | ID: mdl-30385350
Multi-component pesticide residues, especially pesticide residues with synergistic toxicity, are a serious threat to food safety. With risk assessment, we found that Chlorpyrifos (CPF) and Carbofuran (CBF) are 2 pesticide residues with highest risk for Actinidia chinensis planch. The results showed CPF and CBF have a synergistic neurotoxicity on neural cell SK-N-SH. The toxicity was partly depending on oxidative stress (OS) and had effects on cell apoptosis and cell cycle arrest. Furthermore, the toxicity remained on long-term low-dose condition.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carbofurano / Residuos de Plaguicidas / Inhibidores de la Colinesterasa / Cloropirifos / Insecticidas Tipo de estudio: Etiology_studies Límite: Humans Idioma: En Revista: Toxicol In Vitro Asunto de la revista: TOXICOLOGIA Año: 2019 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carbofurano / Residuos de Plaguicidas / Inhibidores de la Colinesterasa / Cloropirifos / Insecticidas Tipo de estudio: Etiology_studies Límite: Humans Idioma: En Revista: Toxicol In Vitro Asunto de la revista: TOXICOLOGIA Año: 2019 Tipo del documento: Article Pais de publicación: Reino Unido