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The use of intracytoplasmic sperm injection is associated with a shift in the secondary sex ratio.
Cirkel, Christoph; König, Inke R; Schultze-Mosgau, Askan; Beck, Elmar; Neumann, Kay; Griesinger, Georg.
Afiliación
  • Cirkel C; Department of Obstetrics and Gynecology, University Hospital Schleswig-Holstein/Campus Luebeck, Ratzeburger Allee 160, Luebeck 23538, Germany. Electronic address: Christoph.Cirkel@uksh.de.
  • König IR; Institute of Medical Biometry and Statistics, University of Luebeck, Luebeck, Germany.
  • Schultze-Mosgau A; Department of Reproductive Medicine and Gynecological Endocrinology, as well as Medical Biometry and Statistics, Ratzeburger Allee 160, Luebeck 23538, Germany.
  • Beck E; Anfomed GmbH, Röttenbacher Str. 17, 91096, Möhrendorf, Germany.
  • Neumann K; Department of Reproductive Medicine and Gynecological Endocrinology, as well as Medical Biometry and Statistics, Ratzeburger Allee 160, Luebeck 23538, Germany.
  • Griesinger G; Department of Reproductive Medicine and Gynecological Endocrinology, as well as Medical Biometry and Statistics, Ratzeburger Allee 160, Luebeck 23538, Germany.
Reprod Biomed Online ; 37(6): 703-708, 2018 Dec.
Article en En | MEDLINE | ID: mdl-30385144
RESEARCH QUESTION: What is the association between assisted reproductive technologies and human sex ratio as a proportion of male offspring at birth. DESIGN: A total of 59,628 singleton deliveries resulting from IVF, intracytoplasmic sperm injection (ICSI) and intrauterine insemination (IUI) or ovulation induction from 101 IVF clinics in Germany, that had been documented in a national German IVF registry, were analysed. Sex ratio after assisted reproductive technology was also compared with the sex ratio reported in the birth records of the German Federal Statistical Office. RESULTS: The sex ratio was 50.0% (95% CI 49.5% to 50.5%) for ICSI, 52.2% (95% CI 51.5% to 52.9%) for IVF, 52.2% (95% CI 50.9% to 53.5%) for IUI or ovulation induction and 51.3% in the national birth records, respectively. Significant differences existed across the three treatment groups (P = 6.86 × 10-7) as well as in pairwise comparisons between ICSI versus IVF (P = 6.88 × 10-7) and ICSI versus IUI or ovulation induction (P = 0.003). No difference existed between the groups IUI or ovulation induction versus IVF. Same results were also present after stratification by maternal age: IVF versus ICSI (P = 6.433 × 10-7), ICSI versus IUI or ovulation induction (P = 0.003), and IVF versus IUI or ovulation induction (non-significant). Compared with the national birth records, ICSI is associated with a lower sex ratio compared with the reference group (P < 0.001), whereas IVF is associated with a higher sex ratio (P = 0.015). CONCLUSIONS: The use of ICSI is associated with an equal proportion of sexes at birth, which is not the case for IVF, IUI or ovulation induction, or natural conception. This phenomenon is not influenced by maternal age.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Razón de Masculinidad / Inyecciones de Esperma Intracitoplasmáticas Tipo de estudio: Risk_factors_studies Límite: Female / Humans / Male País/Región como asunto: Europa Idioma: En Revista: Reprod Biomed Online Asunto de la revista: MEDICINA REPRODUTIVA Año: 2018 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Razón de Masculinidad / Inyecciones de Esperma Intracitoplasmáticas Tipo de estudio: Risk_factors_studies Límite: Female / Humans / Male País/Región como asunto: Europa Idioma: En Revista: Reprod Biomed Online Asunto de la revista: MEDICINA REPRODUTIVA Año: 2018 Tipo del documento: Article Pais de publicación: Países Bajos