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Cilostazol-loaded electrospun three-dimensional systems for potential cardiovascular application: Effect of fibers hydrophilization on drug release, and cytocompatibility.
Rychter, Marek; Milanowski, Bartlomiej; Grzeskowiak, Bartosz F; Jarek, Marcin; Kempinski, Mateusz; Coy, Emerson L; Borysiak, Slawomir; Baranowska-Korczyc, Anna; Lulek, Janina.
Afiliación
  • Rychter M; Department of Pharmaceutical Technology, Faculty of Pharmacy, Poznan University of Medical Sciences, Grunwaldzka 6, 60-780 Poznan, Poland; NanoBioMedical Centre, Adam Mickiewicz University Poznan, Umultowska 85, 61-614 Poznan, Poland. Electronic address: mrychter@ump.edu.pl.
  • Milanowski B; Department of Pharmaceutical Technology, Faculty of Pharmacy, Poznan University of Medical Sciences, Grunwaldzka 6, 60-780 Poznan, Poland.
  • Grzeskowiak BF; NanoBioMedical Centre, Adam Mickiewicz University Poznan, Umultowska 85, 61-614 Poznan, Poland.
  • Jarek M; NanoBioMedical Centre, Adam Mickiewicz University Poznan, Umultowska 85, 61-614 Poznan, Poland.
  • Kempinski M; NanoBioMedical Centre, Adam Mickiewicz University Poznan, Umultowska 85, 61-614 Poznan, Poland; Faculty of Physics, Adam Mickiewicz University in Poznan, Umultowska 85, 61-614 Poznan, Poland.
  • Coy EL; NanoBioMedical Centre, Adam Mickiewicz University Poznan, Umultowska 85, 61-614 Poznan, Poland.
  • Borysiak S; Institute of Chemical Technology and Engineering, Poznan University of Technology, Poznan, Poland.
  • Baranowska-Korczyc A; NanoBioMedical Centre, Adam Mickiewicz University Poznan, Umultowska 85, 61-614 Poznan, Poland; Faculty of Chemistry, University of Warsaw, Pasteura 1, 02-093 Warsaw, Poland.
  • Lulek J; Department of Pharmaceutical Technology, Faculty of Pharmacy, Poznan University of Medical Sciences, Grunwaldzka 6, 60-780 Poznan, Poland.
J Colloid Interface Sci ; 536: 310-327, 2019 Feb 15.
Article en En | MEDLINE | ID: mdl-30380431
Currently marketed drug-eluting stents are non-selective in their anti-restenotic action. New active substance introduction to polymeric stents and vascular grafts can promote early re-endothelialization, crucial in preventing implant restenosis. Additionally, managing material hydrophobicity by blending synthetic polymers limits adverse effects on bulk properties and controls active substance release. However, the influence of hydrophilic synthetic polymer on human cells in the cardiovascular system remains to be determined. In this report, effects of both poly(ε-caprolactone) (PCL) fibers hydrophilization with Pluronic P123 (P123) and cilostazol (CIL) loading were studied. Physicochemical and mechanical properties of electrospun tubular structures produced from PCL and PCL/P123 fibers with and without CIL were investigated and compared. Release profiles studies and in vitro cell proliferation assays of electrospun materials were conducted. It was found that P123 located near the surface of electrospun fibers increased the rate of CIL release. PCL formulation sustained human umbilical vein endothelial cells (HUVEC) growth for 48 h. Despite improved hydrophilicity, PCL/P123 formulations were found to reduce HUVEC viability. Both PCL and PCL/P123 materials reduced primary aortic smooth muscle cells (PASM) viability after 48 h. In PCL formulations containing CIL, drug release caused a decrease in PASM viability. P123 blending with PCL was found to be as a useful pre-fabrication technique for modulating surface hydrophobicity of electrospun materials and the release profile of incorporated active substance. The cytotoxicity of P123 was evaluated to improve the design of drug-loaded vascular grafts for cardiovascular applications.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Poloxaleno / Poliésteres / Sistema Cardiovascular / Liberación de Fármacos / Cilostazol Límite: Humans Idioma: En Revista: J Colloid Interface Sci Año: 2019 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Poloxaleno / Poliésteres / Sistema Cardiovascular / Liberación de Fármacos / Cilostazol Límite: Humans Idioma: En Revista: J Colloid Interface Sci Año: 2019 Tipo del documento: Article Pais de publicación: Estados Unidos