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May the force be with you: Transfer of healthy mitochondria from stem cells to stroke cells.
Borlongan, Cesar V; Nguyen, Hung; Lippert, Trenton; Russo, Eleonora; Tuazon, Julian; Xu, Kaya; Lee, Jea-Young; Sanberg, Paul R; Kaneko, Yuji; Napoli, Eleonora.
Afiliación
  • Borlongan CV; 1 Department of Neurosurgery and Brain Repair, College of Medicine, University of South Florida Morsani, Tampa, FL, USA.
  • Nguyen H; 1 Department of Neurosurgery and Brain Repair, College of Medicine, University of South Florida Morsani, Tampa, FL, USA.
  • Lippert T; 1 Department of Neurosurgery and Brain Repair, College of Medicine, University of South Florida Morsani, Tampa, FL, USA.
  • Russo E; 1 Department of Neurosurgery and Brain Repair, College of Medicine, University of South Florida Morsani, Tampa, FL, USA.
  • Tuazon J; 1 Department of Neurosurgery and Brain Repair, College of Medicine, University of South Florida Morsani, Tampa, FL, USA.
  • Xu K; 1 Department of Neurosurgery and Brain Repair, College of Medicine, University of South Florida Morsani, Tampa, FL, USA.
  • Lee JY; 1 Department of Neurosurgery and Brain Repair, College of Medicine, University of South Florida Morsani, Tampa, FL, USA.
  • Sanberg PR; 1 Department of Neurosurgery and Brain Repair, College of Medicine, University of South Florida Morsani, Tampa, FL, USA.
  • Kaneko Y; 1 Department of Neurosurgery and Brain Repair, College of Medicine, University of South Florida Morsani, Tampa, FL, USA.
  • Napoli E; 2 Department of Molecular Biosciences, University of California Davis, Davis, CA, USA.
J Cereb Blood Flow Metab ; 39(2): 367-370, 2019 02.
Article en En | MEDLINE | ID: mdl-30375940
Stroke is a major cause of death and disability in the United States and around the world with limited therapeutic option. Here, we discuss the critical role of mitochondria in stem cell-mediated rescue of stroke brain by highlighting the concept that deleting the mitochondria from stem cells abolishes the cells' regenerative potency. The application of innovative approaches entailing generation of mitochondria-voided stem cells as well as pharmacological inhibition of mitochondrial function may elucidate the mechanism underlying transfer of healthy mitochondria to ischemic cells, thereby providing key insights in the pathology and treatment of stroke and other brain disorders plagued with mitochondrial dysfunctions.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células Madre / Encéfalo / Accidente Cerebrovascular / Mitocondrias Límite: Animals / Humans Idioma: En Revista: J Cereb Blood Flow Metab Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células Madre / Encéfalo / Accidente Cerebrovascular / Mitocondrias Límite: Animals / Humans Idioma: En Revista: J Cereb Blood Flow Metab Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos