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Vessel-specific quantification of absolute myocardial blood flow, myocardial flow reserve and relative flow reserve by means of fused dynamic 13NH3 PET and CCTA: Ranges in a low-risk population and abnormality criteria.
Piccinelli, Marina; Cho, Sang-Geon; Garcia, Ernest V; Alexanderson, Erick; Lee, Joo Myung; Cooke, C David; Goyal, Nikhil; Sanchez, Mauricio Santos; Folks, Russel D; Chen, Zhengjia; Votaw, John; Koo, Bon-Kwon; Bom, Hee-Seung.
Afiliación
  • Piccinelli M; Department of Radiology and Imaging Sciences, Emory University School of Medicine, 1364 Clifton Rd, NE, Atlanta, GA, 3032, USA. mpiccin@emory.edu.
  • Cho SG; Department of Nuclear Medicine, Chonnam National University, Gwangju, Korea.
  • Garcia EV; Department of Radiology and Imaging Sciences, Emory University School of Medicine, 1364 Clifton Rd, NE, Atlanta, GA, 3032, USA.
  • Alexanderson E; Nuclear Cardiology Department, Instituto Nacional de Cardiologia, Mexico City, Mexico.
  • Lee JM; Heart Vascular Stroke Institute, Samsung Medical Center, Seoul, Korea.
  • Cooke CD; Department of Radiology and Imaging Sciences, Emory University School of Medicine, 1364 Clifton Rd, NE, Atlanta, GA, 3032, USA.
  • Goyal N; Department of Radiology and Imaging Sciences, Emory University School of Medicine, 1364 Clifton Rd, NE, Atlanta, GA, 3032, USA.
  • Sanchez MS; Nuclear Cardiology Department, Instituto Nacional de Cardiologia, Mexico City, Mexico.
  • Folks RD; Department of Radiology and Imaging Sciences, Emory University School of Medicine, 1364 Clifton Rd, NE, Atlanta, GA, 3032, USA.
  • Chen Z; Department of Biostatistics & Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, USA.
  • Votaw J; Department of Radiology and Imaging Sciences, Emory University School of Medicine, 1364 Clifton Rd, NE, Atlanta, GA, 3032, USA.
  • Koo BK; Department of Internal Medicine and Cardiovascular Center, Seoul National University Hospital, Seoul, Korea.
  • Bom HS; Department of Nuclear Medicine, Chonnam National University, Gwangju, Korea.
J Nucl Cardiol ; 27(5): 1756-1769, 2020 10.
Article en En | MEDLINE | ID: mdl-30374847
OBJECTIVES: The goal of the present work is to present a novel methodology for the extraction of MBF, MFR and RFR along coronary arteries by means of multimodality image fusion of dynamic PET and CCTA images. BACKGROUND: FFR is the reference standard to identify flow-limiting lesions, but its invasiveness limits broad application. New noninvasive methodologies are warranted to stratify patients and guide treatment. METHODS: A group of 16 low-risk CAD subjects who underwent both 13NH3 PET and CCTA were analyzed. Image fusion techniques were employed to align the studies and CCTA-derived anatomy used to identify coronaries trajectories. MBF was calculated by means of a 1-tissue compartmental model for the standard vascular territories and along patient-specific vessel paths from the base to the apex of the heart. RESULTS: Low-risk ranges for MBF. MFR and RFR for LAD, LCX and rPDA were computed for the entire cohort and separated by gender. Computed low-risk ranges were used to assess a prospective patient with suspected CAD. CONCLUSIONS: Our vessel-specific functional indexes and 3D displays offer promise to more closely replicate what is commonly performed during a catheterization session and have the potential of providing effective noninvasive tools for the identification of flow-limiting lesions and image-guided therapy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de la Arteria Coronaria / Circulación Coronaria / Tomografía de Emisión de Positrones / Reserva del Flujo Fraccional Miocárdico / Angiografía por Tomografía Computarizada Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Nucl Cardiol Asunto de la revista: CARDIOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de la Arteria Coronaria / Circulación Coronaria / Tomografía de Emisión de Positrones / Reserva del Flujo Fraccional Miocárdico / Angiografía por Tomografía Computarizada Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Nucl Cardiol Asunto de la revista: CARDIOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos