Cytotoxicity of new pyridazin-3(2H)-one derivatives orchestrating oxidative stress in human triple-negative breast cancer (MDA-MB-468).

Bouchmaa, Najat; Ben Mrid, Reda; Boukharsa, Youness; Nhiri, Mohamed; Ait Mouse, Hassan; Taoufik, Jamal; Ansar, M'hammed; Zyad, Abdelmajid

Bouchmaa, Najat; Ben Mrid, Reda; Boukharsa, Youness; Nhiri, Mohamed; Ait Mouse, Hassan; Taoufik, Jamal; Ansar, M'hammed; Zyad, Abdelmajid.

Afiliación

Bouchmaa N; Team of Experimental Oncology and Natural Substances, Cellular and Molecular Immuno-pharmacology, Faculty of Sciences and Techniques, Sultan Moulay Slimane University, Beni-Mellal, Morocco.
Ben Mrid R; Laboratory of Medicinal Chemistry, Faculty of Medicine and Pharmacy, Mohammed V University, Rabat, Morocco.
Boukharsa Y; Laboratory of Biochemistry and Molecular Genetics, Faculty of Sciences and Techniques, Tangier, Morocco.
Nhiri M; Laboratory of Medicinal Chemistry, Faculty of Medicine and Pharmacy, Mohammed V University, Rabat, Morocco.
Ait Mouse H; Laboratory of Biochemistry and Molecular Genetics, Faculty of Sciences and Techniques, Tangier, Morocco.
Taoufik J; Team of Experimental Oncology and Natural Substances, Cellular and Molecular Immuno-pharmacology, Faculty of Sciences and Techniques, Sultan Moulay Slimane University, Beni-Mellal, Morocco.
Ansar M; Laboratory of Medicinal Chemistry, Faculty of Medicine and Pharmacy, Mohammed V University, Rabat, Morocco.
Zyad A; Laboratory of Medicinal Chemistry, Faculty of Medicine and Pharmacy, Mohammed V University, Rabat, Morocco.

Arch Pharm (Weinheim) ; 351(12): e1800128, 2018 Dec.

Article en En | MEDLINE | ID: mdl-30370633

Asunto(s)

Antineoplásicos/farmacología; Estrés Oxidativo/efectos de los fármacos; Piridazinas/farmacología; Neoplasias de la Mama Triple Negativas/metabolismo; Antineoplásicos/síntesis química; Antineoplásicos/química; Línea Celular Tumoral; Supervivencia Celular/efectos de los fármacos; Femenino; Humanos; Concentración 50 Inhibidora; Leucocitos Mononucleares/efectos de los fármacos; Estructura Molecular; Piridazinas/síntesis química; Piridazinas/química; Especies Reactivas de Oxígeno/metabolismo; Neoplasias de la Mama Triple Negativas/patología

Palabras clave

anticancer agent; cytotoxicity; oxidative stress; pyridazin-(2H)-3-ones; triple-negative breast cancer

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piridazinas / Estrés Oxidativo / Neoplasias de la Mama Triple Negativas / Antineoplásicos Límite: Female / Humans Idioma: En Revista: Arch Pharm (Weinheim) Año: 2018 Tipo del documento: Article País de afiliación: Marruecos Pais de publicación: Alemania

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