Your browser doesn't support javascript.
loading
siRNA Blocking of Mammalian Target of Rapamycin (mTOR) Attenuates Pathology in Annonacin-Induced Tauopathy in Mice.
Salama, Mohamed; El-Desouky, Sara; Alsayed, Aziza; El-Hussiny, Mahmoud; Magdy, Khaled; Fekry, Emad; Shabka, Osama; El-Khodery, Sabry A; Youssef, Mohamed A; Sobh, Mohamed; Mohamed, Wael.
Afiliación
  • Salama M; Medical Experimental Research Center (MERC), Faculty of Medicine, Mansoura University, Elgomhourya street, Mansoura, 36551, Egypt. toxicsalama@hotmail.com.
  • El-Desouky S; Toxicology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt. toxicsalama@hotmail.com.
  • Alsayed A; Medical Experimental Research Center (MERC), Faculty of Medicine, Mansoura University, Elgomhourya street, Mansoura, 36551, Egypt.
  • El-Hussiny M; Medical Experimental Research Center (MERC), Faculty of Medicine, Mansoura University, Elgomhourya street, Mansoura, 36551, Egypt.
  • Magdy K; Medical Experimental Research Center (MERC), Faculty of Medicine, Mansoura University, Elgomhourya street, Mansoura, 36551, Egypt.
  • Fekry E; Medical Experimental Research Center (MERC), Faculty of Medicine, Mansoura University, Elgomhourya street, Mansoura, 36551, Egypt.
  • Shabka O; Toxicology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
  • El-Khodery SA; Toxicology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
  • Youssef MA; Internal Medicine Department, Faculty of Veterinary Medicine, Mansoura University, Mansoura, Egypt.
  • Sobh M; Internal Medicine Department, Faculty of Veterinary Medicine, Mansoura University, Mansoura, Egypt.
  • Mohamed W; Urology and Nephrology Center (UNC) Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Neurotox Res ; 35(4): 987-992, 2019 May.
Article en En | MEDLINE | ID: mdl-30362086
Tauopathy is a pathological hallmark of many neurodegenerative diseases. It is characterized by abnormal aggregates of pathological phosphotau and somatodendritic redistribution. One suggested strategy for treating tauopathy is to stimulate autophagy, hence, getting rid of these pathological protein aggregates. One key controller of autophagy is mTOR. Since stimulation of mTOR leads to inhibition of autophagy, inhibitors of mTOR will cause stimulation of autophagy process. In this report, tauopathy was induced in mice using annonacin. Blocking of mTOR was achieved through stereotaxic injection of siRNA against mTOR. The behavioral and immunohistochemical evaluation revealed the development of tauopathy model as proven by deterioration of behavioral performance in open field test and significant tau aggregates in annonacin-treated mice. Blocking of mTOR revealed significant clearance of tau aggregates in the injected side; however, tau expression was not affected by mTOR blockage.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encéfalo / Tauopatías / Serina-Treonina Quinasas TOR / Neuronas Límite: Animals Idioma: En Revista: Neurotox Res Asunto de la revista: NEUROLOGIA Año: 2019 Tipo del documento: Article País de afiliación: Egipto Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encéfalo / Tauopatías / Serina-Treonina Quinasas TOR / Neuronas Límite: Animals Idioma: En Revista: Neurotox Res Asunto de la revista: NEUROLOGIA Año: 2019 Tipo del documento: Article País de afiliación: Egipto Pais de publicación: Estados Unidos