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Nanoparticles in Medicine: A Focus on Vascular Oxidative Stress.
Mauricio, M D; Guerra-Ojeda, S; Marchio, P; Valles, S L; Aldasoro, M; Escribano-Lopez, I; Herance, J R; Rocha, M; Vila, J M; Victor, V M.
Afiliación
  • Mauricio MD; Department of Physiology, Faculty of Medicine and Odontology, Universitat de Valencia and Institute of Health Research INCLIVA, Valencia, Spain.
  • Guerra-Ojeda S; Department of Physiology, Faculty of Medicine and Odontology, Universitat de Valencia and Institute of Health Research INCLIVA, Valencia, Spain.
  • Marchio P; Department of Physiology, Faculty of Medicine and Odontology, Universitat de Valencia and Institute of Health Research INCLIVA, Valencia, Spain.
  • Valles SL; Department of Physiology, Faculty of Medicine and Odontology, Universitat de Valencia and Institute of Health Research INCLIVA, Valencia, Spain.
  • Aldasoro M; Department of Physiology, Faculty of Medicine and Odontology, Universitat de Valencia and Institute of Health Research INCLIVA, Valencia, Spain.
  • Escribano-Lopez I; Service of Endocrinology, University Hospital Doctor Peset, Foundation for the Promotion of Health and Biomedical Research in the Valencian Region (FISABIO), Valencia, Spain.
  • Herance JR; Medical Molecular Imaging Research Group, Vall d'Hebron Research Institute (VHIR), CIBBIM Nanomedicine, Passeig de la Vall d'Hebron, Barcelona, Spain.
  • Rocha M; Service of Endocrinology, University Hospital Doctor Peset, Foundation for the Promotion of Health and Biomedical Research in the Valencian Region (FISABIO), Valencia, Spain.
  • Vila JM; Department of Physiology, Faculty of Medicine and Odontology, Universitat de Valencia and Institute of Health Research INCLIVA, Valencia, Spain.
  • Victor VM; Department of Physiology, Faculty of Medicine and Odontology, Universitat de Valencia and Institute of Health Research INCLIVA, Valencia, Spain.
Oxid Med Cell Longev ; 2018: 6231482, 2018.
Article en En | MEDLINE | ID: mdl-30356429
Nanotechnology has had a significant impact on medicine in recent years, its application being referred to as nanomedicine. Nanoparticles have certain properties with biomedical applications; however, in some situations, they have demonstrated cell toxicity, which has caused concern surrounding their clinical use. In this review, we focus on two aspects: first, we summarize the types of nanoparticles according to their chemical composition and the general characteristics of their use in medicine, and second, we review the applications of nanoparticles in vascular alteration, especially in endothelial dysfunction related to oxidative stress. This condition can lead to a reduction in nitric oxide (NO) bioavailability, consequently affecting vascular tone regulation and endothelial dysfunction, which is the first phase in the development of cardiovascular diseases. Therefore, nanoparticles with antioxidant properties may improve vascular dysfunction associated with hypertension, diabetes mellitus, or atherosclerosis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vasos Sanguíneos / Estrés Oxidativo / Nanomedicina / Nanopartículas Límite: Animals / Humans Idioma: En Revista: Oxid Med Cell Longev Asunto de la revista: METABOLISMO Año: 2018 Tipo del documento: Article País de afiliación: España Pais de publicación: Estados Unidos
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vasos Sanguíneos / Estrés Oxidativo / Nanomedicina / Nanopartículas Límite: Animals / Humans Idioma: En Revista: Oxid Med Cell Longev Asunto de la revista: METABOLISMO Año: 2018 Tipo del documento: Article País de afiliación: España Pais de publicación: Estados Unidos