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A four-component radical cascade trifluoromethylation reaction of alkenes enabled by an electron-donor-acceptor complex.
Tu, Hai-Yong; Zhu, Shengqing; Qing, Feng-Ling; Chu, Lingling.
Afiliación
  • Tu HY; State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Chemistry, Chemical Engineering and Biotechnology, Center for Advanced Low-Dimension Materials, Donghua University, Shanghai 201620, China. lingling.chu1@dhu.edu.cn.
Chem Commun (Camb) ; 54(90): 12710-12713, 2018 Nov 08.
Article en En | MEDLINE | ID: mdl-30345997
An efficient four-component radical cascade reaction of alkenes, enabled by an EDA complex between Togni's reagent and Hantzsch ester, has been reported. This operationally simple protocol demonstrates excellent selectivity, which is dominated by the innate polar effect, providing facile access to important δ-CF3 carbonyls under mild conditions. To further demonstrate the wide synthetic utility of this method, a three-step synthesis of CF3-naftidrofuryl has been successfully conducted.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Chem Commun (Camb) Asunto de la revista: QUIMICA Año: 2018 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Chem Commun (Camb) Asunto de la revista: QUIMICA Año: 2018 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido