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Voltage-sensitive dye delivery through the blood brain barrier using adenosine receptor agonist regadenoson.
Pak, Rebecca W; Kang, Jeeun; Valentine, Heather; Loew, Leslie M; Thorek, Daniel L J; Boctor, Emad M; Wong, Dean F; Kang, Jin U.
Afiliación
  • Pak RW; Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Kang J; Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Valentine H; Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Loew LM; R.D. Berlin Center for Cell Analysis and Modeling, University of Connecticut School of Medicine, Farmington, CT, USA.
  • Thorek DLJ; Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Boctor EM; Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Wong DF; Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Kang JU; Electrical and Computer Engineering, Johns Hopkins University Whiting School of Engineering, Baltimore, MD, USA.
Biomed Opt Express ; 9(8): 3915-3922, 2018 Aug 01.
Article en En | MEDLINE | ID: mdl-30338164
Optical imaging of brain activity has mostly employed genetically manipulated mice, which cannot be translated to clinical human usage. Observation of brain activity directly is challenging due to the difficulty in delivering dyes and other agents through the blood brain barrier (BBB). Using fluorescence imaging, we have demonstrated the feasibility of delivering the near-infrared voltage-sensitive dye (VSD) IR-780 perchlorate to the brain tissue through pharmacological techniques, via an adenosine agonist (regadenoson). Comparison of VSD fluorescence of mouse brains without and with regadenoson showed significantly increased residence time of the fluorescence signal in the latter case, indicative of VSD diffusion into the brain tissue. Dose and timing of regadenoson were varied to optimize BBB permeability for VSD delivery.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Diagnostic_studies Aspecto: Implementation_research Idioma: En Revista: Biomed Opt Express Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Diagnostic_studies Aspecto: Implementation_research Idioma: En Revista: Biomed Opt Express Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos