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BATLAS: Deconvoluting Brown Adipose Tissue.
Perdikari, Aliki; Leparc, Germán Gastón; Balaz, Miroslav; Pires, Nuno D; Lidell, Martin E; Sun, Wenfei; Fernandez-Albert, Francesc; Müller, Sebastian; Akchiche, Nassila; Dong, Hua; Balazova, Lucia; Opitz, Lennart; Röder, Eva; Klein, Holger; Stefanicka, Patrik; Varga, Lukas; Nuutila, Pirjo; Virtanen, Kirsi A; Niemi, Tarja; Taittonen, Markku; Rudofsky, Gottfried; Ukropec, Jozef; Enerbäck, Sven; Stupka, Elia; Neubauer, Heike; Wolfrum, Christian.
Afiliación
  • Perdikari A; Institute of Food, Nutrition and Health, ETH Zurich, Schwerzenbach, Switzerland.
  • Leparc GG; Target Discovery Research Department, Boehringer Ingelheim Pharma GmbH and Co. KG, Biberach/Riss, Germany.
  • Balaz M; Institute of Food, Nutrition and Health, ETH Zurich, Schwerzenbach, Switzerland.
  • Pires ND; Institute of Food, Nutrition and Health, ETH Zurich, Schwerzenbach, Switzerland.
  • Lidell ME; Department of Medical and Clinical Genetics, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
  • Sun W; Institute of Food, Nutrition and Health, ETH Zurich, Schwerzenbach, Switzerland.
  • Fernandez-Albert F; Target Discovery Research Department, Boehringer Ingelheim Pharma GmbH and Co. KG, Biberach/Riss, Germany.
  • Müller S; Institute of Food, Nutrition and Health, ETH Zurich, Schwerzenbach, Switzerland.
  • Akchiche N; Institute of Food, Nutrition and Health, ETH Zurich, Schwerzenbach, Switzerland.
  • Dong H; Institute of Food, Nutrition and Health, ETH Zurich, Schwerzenbach, Switzerland.
  • Balazova L; Institute of Food, Nutrition and Health, ETH Zurich, Schwerzenbach, Switzerland.
  • Opitz L; Institute of Food, Nutrition and Health, ETH Zurich, Schwerzenbach, Switzerland.
  • Röder E; Institute of Food, Nutrition and Health, ETH Zurich, Schwerzenbach, Switzerland.
  • Klein H; Target Discovery Research Department, Boehringer Ingelheim Pharma GmbH and Co. KG, Biberach/Riss, Germany.
  • Stefanicka P; Department of Otorhinolaryngology - Head and Neck Surgery, Faculty of Medicine and University Hospital, Comenius University, Bratislava, Slovakia.
  • Varga L; Department of Otorhinolaryngology - Head and Neck Surgery, Faculty of Medicine and University Hospital, Comenius University, Bratislava, Slovakia; Institute of Experimental Endocrinology, Biomedical Research Center at the Slovak Academy of Sciences, Bratislava, Slovakia.
  • Nuutila P; Turku PET Centre, University of Turku, Turku, Finland.
  • Virtanen KA; Turku PET Centre, University of Turku, Turku, Finland.
  • Niemi T; Department of Surgery, Turku University Hospital, Turku, Finland.
  • Taittonen M; Department of Anesthesiology, Turku University Hospital, Turku, Finland.
  • Rudofsky G; Endocrinology and Metabolic Diseases, Cantonal Hospital Olten, Olten, Switzerland.
  • Ukropec J; Institute of Experimental Endocrinology, Biomedical Research Center at the Slovak Academy of Sciences, Bratislava, Slovakia.
  • Enerbäck S; Department of Medical and Clinical Genetics, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
  • Stupka E; Target Discovery Research Department, Boehringer Ingelheim Pharma GmbH and Co. KG, Biberach/Riss, Germany.
  • Neubauer H; Cardiometabolic Diseases Research Department, Boehringer Ingelheim Pharma GmbH and Co. KG, Biberach/Riss, Germany. Electronic address: heike.neubauer@boehringer-ingelheim.com.
  • Wolfrum C; Institute of Food, Nutrition and Health, ETH Zurich, Schwerzenbach, Switzerland. Electronic address: christian-wolfrum@ethz.ch.
Cell Rep ; 25(3): 784-797.e4, 2018 10 16.
Article en En | MEDLINE | ID: mdl-30332656
Recruitment and activation of thermogenic adipocytes have received increasing attention as a strategy to improve systemic metabolic control. The analysis of brown and brite adipocytes is complicated by the complexity of adipose tissue biopsies. Here, we provide an in-depth analysis of pure brown, brite, and white adipocyte transcriptomes. By combining mouse and human transcriptome data, we identify a gene signature that can classify brown and white adipocytes in mice and men. Using a machine-learning-based cell deconvolution approach, we develop an algorithm proficient in calculating the brown adipocyte content in complex human and mouse biopsies. Applying this algorithm, we can show in a human weight loss study that brown adipose tissue (BAT) content is associated with energy expenditure and the propensity to lose weight. This online available tool can be used for in-depth characterization of complex adipose tissue samples and may support the development of therapeutic strategies to increase energy expenditure in humans.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Programas Informáticos / Tejido Adiposo Pardo / Biomarcadores / Biología Computacional / Tejido Adiposo Blanco / Obesidad Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Cell Rep Año: 2018 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Estados Unidos
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Programas Informáticos / Tejido Adiposo Pardo / Biomarcadores / Biología Computacional / Tejido Adiposo Blanco / Obesidad Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Cell Rep Año: 2018 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Estados Unidos