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Transforming Growth Factor-ß3 Regulates Adipocyte Number in Subcutaneous White Adipose Tissue.
Petrus, Paul; Mejhert, Niklas; Corrales, Patricia; Lecoutre, Simon; Li, Qian; Maldonado, Estela; Kulyté, Agne; Lopez, Yamila; Campbell, Mark; Acosta, Juan R; Laurencikiene, Jurga; Douagi, Iyadh; Gao, Hui; Martínez-Álvarez, Concepción; Hedén, Per; Spalding, Kirsty L; Vidal-Puig, Antonio; Medina-Gomez, Gema; Arner, Peter; Rydén, Mikael.
Afiliación
  • Petrus P; Department of Medicine (H7), Karolinska Institutet, Stockholm 141 86, Sweden.
  • Mejhert N; Department of Medicine (H7), Karolinska Institutet, Stockholm 141 86, Sweden.
  • Corrales P; Departamento de Ciencias Básicas de la Salud, Área Bioquímica y Biología Molecular, Facultad de Ciencias de la Salud, Universidad Rey Juan Carlos, Alcorcón 289 22, Madrid, Spain.
  • Lecoutre S; Department of Medicine (H7), Karolinska Institutet, Stockholm 141 86, Sweden.
  • Li Q; Department of Medicine (H7), Karolinska Institutet, Stockholm 141 86, Sweden.
  • Maldonado E; Departamento de Anatomía y Embriología, Facultad de Medicina, Facultad de Odontología, Universidad Complutense, Madrid 28040, Spain.
  • Kulyté A; Department of Medicine (H7), Karolinska Institutet, Stockholm 141 86, Sweden.
  • Lopez Y; Departamento de Ciencias Básicas de la Salud, Área Bioquímica y Biología Molecular, Facultad de Ciencias de la Salud, Universidad Rey Juan Carlos, Alcorcón 289 22, Madrid, Spain.
  • Campbell M; MRC MDU, Metabolic Research Laboratories, Institute of Metabolic Science, Box 289, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK.
  • Acosta JR; Department of Medicine (H7), Karolinska Institutet, Stockholm 141 86, Sweden.
  • Laurencikiene J; Department of Medicine (H7), Karolinska Institutet, Stockholm 141 86, Sweden.
  • Douagi I; Department of Medicine (H7), Karolinska Institutet, Stockholm 141 86, Sweden.
  • Gao H; Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm 141 86, Sweden.
  • Martínez-Álvarez C; Departamento de Anatomía y Embriología, Facultad de Medicina, Facultad de Odontología, Universidad Complutense, Madrid 28040, Spain.
  • Hedén P; Akademikliniken, Storängsvägen 10, Stockholm 115 42, Sweden.
  • Spalding KL; Department of Medicine (H7), Karolinska Institutet, Stockholm 141 86, Sweden.
  • Vidal-Puig A; MRC MDU, Metabolic Research Laboratories, Institute of Metabolic Science, Box 289, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK.
  • Medina-Gomez G; Departamento de Ciencias Básicas de la Salud, Área Bioquímica y Biología Molecular, Facultad de Ciencias de la Salud, Universidad Rey Juan Carlos, Alcorcón 289 22, Madrid, Spain. Electronic address: gema.medina@urjc.es.
  • Arner P; Department of Medicine (H7), Karolinska Institutet, Stockholm 141 86, Sweden.
  • Rydén M; Department of Medicine (H7), Karolinska Institutet, Stockholm 141 86, Sweden. Electronic address: mikael.ryden@ki.se.
Cell Rep ; 25(3): 551-560.e5, 2018 10 16.
Article en En | MEDLINE | ID: mdl-30332637
White adipose tissue (WAT) mass is determined by adipocyte size and number. While adipocytes are continuously turned over, the mechanisms controlling fat cell number in WAT upon weight changes are unclear. Herein, prospective studies of human subcutaneous WAT demonstrate that weight gain increases both adipocyte size and number, but the latter remains unaltered after weight loss. Transcriptome analyses associate changes in adipocyte number with the expression of 79 genes. This gene set is enriched for growth factors, out of which one, transforming growth factor-ß3 (TGFß3), stimulates adipocyte progenitor proliferation, resulting in a higher number of cells undergoing differentiation in vitro. The relevance of these observations was corroborated in vivo where Tgfb3+/- mice, in comparison with wild-type littermates, display lower subcutaneous adipocyte progenitor proliferation, WAT hypertrophy, and glucose intolerance. TGFß3 is therefore a regulator of subcutaneous adipocyte number and may link WAT morphology to glucose metabolism.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Intolerancia a la Glucosa / Grasa Subcutánea / Adipogénesis / Tejido Adiposo Blanco / Factor de Crecimiento Transformador beta3 / Obesidad Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Adolescent / Animals / Female / Humans / Male Idioma: En Revista: Cell Rep Año: 2018 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Estados Unidos
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Intolerancia a la Glucosa / Grasa Subcutánea / Adipogénesis / Tejido Adiposo Blanco / Factor de Crecimiento Transformador beta3 / Obesidad Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Adolescent / Animals / Female / Humans / Male Idioma: En Revista: Cell Rep Año: 2018 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Estados Unidos