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Therapeutic potential of melatonin related to its role as an autophagy regulator: A review.
Boga, Jose A; Caballero, Beatriz; Potes, Yaiza; Perez-Martinez, Zulema; Reiter, Russel J; Vega-Naredo, Ignacio; Coto-Montes, Ana.
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  • Boga JA; Service of Microbiology, Hospital Universitario Central de Asturias (HUCA), Oviedo, Spain.
  • Caballero B; Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain.
  • Potes Y; Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain.
  • Perez-Martinez Z; Department of Morphology and Cell Biology, University of Oviedo, Oviedo, Spain.
  • Reiter RJ; Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain.
  • Vega-Naredo I; Department of Morphology and Cell Biology, University of Oviedo, Oviedo, Spain.
  • Coto-Montes A; Service of Microbiology, Hospital Universitario Central de Asturias (HUCA), Oviedo, Spain.
J Pineal Res ; 66(1): e12534, 2019 Jan.
Article en En | MEDLINE | ID: mdl-30329173
There are several pathologies, syndromes, and physiological processes in which autophagy is involved. This process of self-digestion that cells trigger as a survival mechanism is complex and tightly regulated, according to the homeostatic conditions of the organ. However, in all cases, its relationship with oxidative stress alterations is evident, following a pathway that suggests endoplasmic reticulum stress and/or mitochondrial changes. There is accumulating evidence of the beneficial role that melatonin has in the regulation and restoration of damaged autophagic processes. In this review, we focus on major physiological changes such as aging and essential pathologies including cancer, neurodegenerative diseases, viral infections and obesity, and document the essential role of melatonin in the regulation of autophagy in each of these different situations.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Autofagia / Melatonina Límite: Animals / Humans Idioma: En Revista: J Pineal Res Asunto de la revista: ENDOCRINOLOGIA Año: 2019 Tipo del documento: Article País de afiliación: España Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Autofagia / Melatonina Límite: Animals / Humans Idioma: En Revista: J Pineal Res Asunto de la revista: ENDOCRINOLOGIA Año: 2019 Tipo del documento: Article País de afiliación: España Pais de publicación: Reino Unido