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Phenome-wide association studies across large population cohorts support drug target validation.
Diogo, Dorothée; Tian, Chao; Franklin, Christopher S; Alanne-Kinnunen, Mervi; March, Michael; Spencer, Chris C A; Vangjeli, Ciara; Weale, Michael E; Mattsson, Hannele; Kilpeläinen, Elina; Sleiman, Patrick M A; Reilly, Dermot F; McElwee, Joshua; Maranville, Joseph C; Chatterjee, Arnaub K; Bhandari, Aman; Nguyen, Khanh-Dung H; Estrada, Karol; Reeve, Mary-Pat; Hutz, Janna; Bing, Nan; John, Sally; MacArthur, Daniel G; Salomaa, Veikko; Ripatti, Samuli; Hakonarson, Hakon; Daly, Mark J; Palotie, Aarno; Hinds, David A; Donnelly, Peter; Fox, Caroline S; Day-Williams, Aaron G; Plenge, Robert M; Runz, Heiko.
Afiliación
  • Diogo D; Merck Sharp & Dohme, Boston, MA, 02115, USA. dorothee.diogo@merck.com.
  • Tian C; 23andMe Inc, Mountain View, CA, 94041, USA.
  • Franklin CS; Genomics plc, Oxford, OX1 1JD, UK.
  • Alanne-Kinnunen M; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014, Helsinki, Finland.
  • March M; The Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA, 19104, USA.
  • Spencer CCA; Genomics plc, Oxford, OX1 1JD, UK.
  • Vangjeli C; Genomics plc, Oxford, OX1 1JD, UK.
  • Weale ME; Genomics plc, Oxford, OX1 1JD, UK.
  • Mattsson H; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014, Helsinki, Finland.
  • Kilpeläinen E; National Institute for Health and Welfare, FI-00271, Helsinki, Finland.
  • Sleiman PMA; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014, Helsinki, Finland.
  • Reilly DF; The Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA, 19104, USA.
  • McElwee J; Merck Sharp & Dohme, Boston, MA, 02115, USA.
  • Maranville JC; Merck Sharp & Dohme, Boston, MA, 02115, USA.
  • Chatterjee AK; Nimbus Therapeutics, Cambridge, MA, 02139, USA.
  • Bhandari A; Merck Sharp & Dohme, Boston, MA, 02115, USA.
  • Nguyen KH; Celgene, Cambridge, MA, 02140, USA.
  • Estrada K; Merck Sharp & Dohme, Boston, MA, 02115, USA.
  • Reeve MP; McKinsey & Co., Boston, MA, 02210, USA.
  • Hutz J; Merck Sharp & Dohme, Boston, MA, 02115, USA.
  • Bing N; Vertex Pharmaceuticals, Boston, MA, 02210, USA.
  • John S; Biogen, Research and Early Development, Cambridge, MA, 02142, USA.
  • MacArthur DG; Biogen, Research and Early Development, Cambridge, MA, 02142, USA.
  • Salomaa V; Eisai, Andover, MA, 01810, USA.
  • Ripatti S; Eisai, Andover, MA, 01810, USA.
  • Hakonarson H; Pfizer, Cambridge, MA, 02139, USA.
  • Daly MJ; Biogen, Research and Early Development, Cambridge, MA, 02142, USA.
  • Palotie A; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.
  • Hinds DA; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, 02114, USA.
  • Donnelly P; National Institute for Health and Welfare, FI-00271, Helsinki, Finland.
  • Fox CS; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014, Helsinki, Finland.
  • Day-Williams AG; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.
  • Plenge RM; Department of Public Health, University of Helsinki, Helsinki, Finland.
  • Runz H; The Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA, 19104, USA.
Nat Commun ; 9(1): 4285, 2018 10 16.
Article en En | MEDLINE | ID: mdl-30327483
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polimorfismo de Nucleótido Simple / Descubrimiento de Drogas / Estudio de Asociación del Genoma Completo Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Límite: Humans País/Región como asunto: Europa Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polimorfismo de Nucleótido Simple / Descubrimiento de Drogas / Estudio de Asociación del Genoma Completo Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Límite: Humans País/Región como asunto: Europa Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido