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Cytotoxicity and genotoxicity of light emitted by incandescent, halogen, and LED bulbs on ARPE-19 and BEAS-2B cell lines.
Gea, Marta; Schilirò, Tiziana; Iacomussi, Paola; Degan, Raffaella; Bonetta, Sara; Gilli, Giorgio.
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  • Gea M; a Department of Public Health and Pediatrics , University of Torino , Torino , Italy.
  • Schilirò T; a Department of Public Health and Pediatrics , University of Torino , Torino , Italy.
  • Iacomussi P; b Italian National Metrological Institute , INRIM , Torino , Italy.
  • Degan R; a Department of Public Health and Pediatrics , University of Torino , Torino , Italy.
  • Bonetta S; a Department of Public Health and Pediatrics , University of Torino , Torino , Italy.
  • Gilli G; a Department of Public Health and Pediatrics , University of Torino , Torino , Italy.
J Toxicol Environ Health A ; 81(19): 998-1014, 2018.
Article en En | MEDLINE | ID: mdl-30325709
LED technology has the extraordinary ability to reduce energy consumption, constituting an economic and ecological advantage, so it is planned to replace incandescent, halogen and other inefficient bulbs for public and domestic lighting with LEDs. LEDs present specific spectral and energetic characteristics compared with those of other domestic light sources, so the potential risks for human health of these bulbs need to be explored. The aim of this study was to assess cytotoxicity and genotoxicity of light emitted by different commercial light bulbs: incandescent, halogen, and two LED bulbs with different correlated color temperatures. The evaluation was done on ARPE-19 as a specific cell model for eye toxicity and on BEAS-2B as a good cell model for toxicology tests. Light induced mainly cytotoxic effects on ARPE-19 and DNA damage on BEAS-2B, so different cell lines showed different biological responses. Moreover, our findings indicate that among the four bulbs, cold LED caused the highest cytotoxic effect on ARPE-19 and the highest genotoxic and oxidative effect on BEAS-2B. Cold LED is probably able to cause more cellular damage because it contains more high-energy radiations (blue). These results suggest that LED technology could be a safe alternative to older technologies, but the use of warm LED should be preferred to cold LED, which can potentially cause adverse effects on retinal cells.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Mucosa Respiratoria / Epitelio Pigmentado de la Retina / Luz Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: J Toxicol Environ Health A Asunto de la revista: SAUDE AMBIENTAL / TOXICOLOGIA Año: 2018 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Mucosa Respiratoria / Epitelio Pigmentado de la Retina / Luz Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: J Toxicol Environ Health A Asunto de la revista: SAUDE AMBIENTAL / TOXICOLOGIA Año: 2018 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Reino Unido