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Discovery of heterocyclic replacements for the coumarin core of anti-tubercular FadD32 inhibitors.
Fang, Chao; Lee, Katie K; Nietupski, Raymond; Bates, Robert H; Fernandez-Menendez, Raquel; Lopez-Roman, Eva Maria; Guijarro-Lopez, Laura; Yin, Yunxing; Peng, Zuozhong; Gomez, James E; Fisher, Stewart; Barros-Aguirre, David; Hubbard, Brian K; Serrano-Wu, Michael H; Hung, Deborah T.
Afiliación
  • Fang C; The Broad Institute of MIT and Harvard, 415 Main St, Cambridge, MA 02142, USA.
  • Lee KK; The Broad Institute of MIT and Harvard, 415 Main St, Cambridge, MA 02142, USA; Department of Molecular Biology and Center for Integrative and Computational Biology, Massachusetts General Hospital, 185 Cambridge St, Boston, MA 02114, USA.
  • Nietupski R; The Broad Institute of MIT and Harvard, 415 Main St, Cambridge, MA 02142, USA.
  • Bates RH; Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, 28760 Madrid, Spain.
  • Fernandez-Menendez R; Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, 28760 Madrid, Spain.
  • Lopez-Roman EM; Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, 28760 Madrid, Spain.
  • Guijarro-Lopez L; Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, 28760 Madrid, Spain.
  • Yin Y; WuXi AppTec, 168 Nanhai Rd, Tianjin Economic-Technological Development Area (TEDA), Tianjin 300457, China.
  • Peng Z; WuXi AppTec, 288 Fute Zhong Rd, Waigaoqiao Free Trade Zone, Shanghai 200131, China.
  • Gomez JE; The Broad Institute of MIT and Harvard, 415 Main St, Cambridge, MA 02142, USA; Department of Molecular Biology and Center for Integrative and Computational Biology, Massachusetts General Hospital, 185 Cambridge St, Boston, MA 02114, USA.
  • Fisher S; The Broad Institute of MIT and Harvard, 415 Main St, Cambridge, MA 02142, USA.
  • Barros-Aguirre D; Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, 28760 Madrid, Spain.
  • Hubbard BK; The Broad Institute of MIT and Harvard, 415 Main St, Cambridge, MA 02142, USA.
  • Serrano-Wu MH; The Broad Institute of MIT and Harvard, 415 Main St, Cambridge, MA 02142, USA.
  • Hung DT; The Broad Institute of MIT and Harvard, 415 Main St, Cambridge, MA 02142, USA; Department of Molecular Biology and Center for Integrative and Computational Biology, Massachusetts General Hospital, 185 Cambridge St, Boston, MA 02114, USA; Department of Genetics, Harvard Medical School, 77 Avenue Loui
Bioorg Med Chem Lett ; 28(22): 3529-3533, 2018 12 01.
Article en En | MEDLINE | ID: mdl-30316633
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas Bacterianas / Cumarinas / Antituberculosos Límite: Animals Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas Bacterianas / Cumarinas / Antituberculosos Límite: Animals Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido