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Increased mitochondrial DNA copy number in maternal peripheral blood is associated with low birth weight in Lombok, Indonesia.
Priliani, L; Febinia, C A; Kamal, B; Shankar, A H; Malik, S G.
Afiliación
  • Priliani L; Eijkman Institute for Molecular Biology, Ministry of Research, Technology and Higher Education, Jalan Diponegoro no. 69, Jakarta, 10430, Indonesia.
  • Febinia CA; Eijkman Institute for Molecular Biology, Ministry of Research, Technology and Higher Education, Jalan Diponegoro no. 69, Jakarta, 10430, Indonesia.
  • Kamal B; Eijkman Institute for Molecular Biology, Ministry of Research, Technology and Higher Education, Jalan Diponegoro no. 69, Jakarta, 10430, Indonesia; Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Depok, Indonesia.
  • Shankar AH; Summit Institute of Development, Mataram, Nusa Tenggara Barat, Indonesia; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA. Electronic address: ashankar@hsph.harvard.edu.
  • Malik SG; Eijkman Institute for Molecular Biology, Ministry of Research, Technology and Higher Education, Jalan Diponegoro no. 69, Jakarta, 10430, Indonesia. Electronic address: ina@eijkman.go.id.
Placenta ; 70: 1-3, 2018 10.
Article en En | MEDLINE | ID: mdl-30316321
Fetal development depends on maternal metabolic energy from mitochondria. We investigated the association of maternal mitochondrial function, represented by mitochondrial DNA copy number (mtDNA-CN) of venous blood, with child birth weight (BW) from 528 randomly selected mothers enrolled in the Supplementation with Multiple Micronutrients Intervention Trial (ISRCTN 34151616). Real-time quantitative PCR of archived blood specimens and regression analysis adjusting for other primary determinants of BW showed that loge mtDNA-CN was inversely associated with BW (ß = -204.6, p < 0.001), particularly in the third trimester (ß = -376.8, p<0.001). Maternal mtDNA-CN may be a marker for low BW and fetal growth restriction.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Peso al Nacer / ADN Mitocondrial / Recién Nacido de Bajo Peso / Variaciones en el Número de Copia de ADN Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Female / Humans / Male / Newborn / Pregnancy País/Región como asunto: Asia Idioma: En Revista: Placenta Año: 2018 Tipo del documento: Article País de afiliación: Indonesia Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Peso al Nacer / ADN Mitocondrial / Recién Nacido de Bajo Peso / Variaciones en el Número de Copia de ADN Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Female / Humans / Male / Newborn / Pregnancy País/Región como asunto: Asia Idioma: En Revista: Placenta Año: 2018 Tipo del documento: Article País de afiliación: Indonesia Pais de publicación: Países Bajos