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The present profile of chronic hepatitis B virus infection highlights future challenges: An analysis of the Multicenter Italian MASTER-B cohort.
Brancaccio, Giuseppina; Nardi, Alessandra; Madonia, Salvatore; Fasano, Massimo; Verucchi, Gabriella; Massari, Marco; Maimone, Sergio; Contini, Carlo; Levantesi, Fabio; Alfieri, Arianna; Gavrila, Caius; Andreone, Pietro; Milella, Michele; Gaeta, Giovanni B.
Afiliación
  • Brancaccio G; Department of Molecular Medicine, Infectious Diseases, University of Padua, Italy; Infectious Diseases, Campania University "Luigi Vanvitelli", Naples, Italy. Electronic address: giuseppina.brancaccio@unipd.it.
  • Nardi A; Department of Mathematics, University of Rome Tor Vergata, Rome, Italy.
  • Madonia S; Internal Medicine, V. Cervello Hospital, Palermo, Italy.
  • Fasano M; Infectious Diseases, University of Foggia, Foggia, Italy; Infectious Diseases, Fallacara Hospital, Triggiano, Italy.
  • Verucchi G; Infectious Diseases, University Hospital of Bologna, Bologna, Italy.
  • Massari M; Infectious Diseases, Azienda Ospedaliera, Reggio Emilia, Italy.
  • Maimone S; Division of Clinical and Molecular Hepatology, University Hospital of Messina, Messina, Italy.
  • Contini C; Infectious Diseases, University Hospital, Ferrara, Italy.
  • Levantesi F; Internal Medicine, Hospital Bentivoglio, Italy.
  • Alfieri A; Infectious Diseases, Azienda Ospedaliera, Parma, Italy.
  • Gavrila C; I.C. Antonio Rosmini, Rome, Italy.
  • Andreone P; Research Center for the Study of Hepatitis, Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.
  • Milella M; Infectious Diseases, University of Bari, Bari, Italy.
  • Gaeta GB; Infectious Diseases, Campania University "Luigi Vanvitelli", Naples, Italy.
Dig Liver Dis ; 51(3): 438-442, 2019 03.
Article en En | MEDLINE | ID: mdl-30314950
BACKGROUND: Chronic hepatitis B virus (HBV) infection remains a primary cause of morbidity and mortality worldwide. AIM: The study is aimed at updating the clinical and epidemiological profile of chronic HBV infection in Italy. METHODS: A cross-sectional multicenter prospective study enrolled consecutive HBsAg positive patients seen in 73 Italian centers in the period 2012-2015. Individual patient data were collected using an electronic platform and analyzed using standard statistical methods. RESULTS: Among 2877 HBsAg positive individuals (median age 49.8 years, 68% males), 27% were non-Italian natives (NINs); 20% had chronic infection, 58.5% chronic hepatitis and 21.5% cirrhosis. Among NINs, age was younger, male gender was less prevalent and liver disease less advanced than in Italians (all p < 0.0001). HBeAg positive cases were 23.6% among NINs vs 8.2% in Italians (p < 0.0001); HDV coinfections 11.1% vs 7.3% (p = 0.006) and HCV coinfections 2.3% vs 4.2% (p = 0.017), respectively. Anti-HDV or anti-HCV antibodies were detected more frequently in patients with cirrhosis. Fifty percent of NINs with cirrhosis were aged below 45 years. CONCLUSION: The study offers an insight into the evolving burden of chronic hepatitis B virus infection in the near future and highlights new territories for public health interventions.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hepatitis D / Hepatitis C / Hepatitis B Crónica / Coinfección / Cirrosis Hepática Tipo de estudio: Clinical_trials / Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Dig Liver Dis Asunto de la revista: GASTROENTEROLOGIA Año: 2019 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hepatitis D / Hepatitis C / Hepatitis B Crónica / Coinfección / Cirrosis Hepática Tipo de estudio: Clinical_trials / Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Dig Liver Dis Asunto de la revista: GASTROENTEROLOGIA Año: 2019 Tipo del documento: Article Pais de publicación: Países Bajos