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Genome-wide association identifies methane production level relation to genetic control of digestive tract development in dairy cows.
Pszczola, M; Strabel, T; Mucha, S; Sell-Kubiak, E.
Afiliación
  • Pszczola M; Department of Genetics and Animal Breeding, Poznan University of Life Sciences, Wolynska 33, Poznan, Poland. mbee@up.poznan.pl.
  • Strabel T; Department of Genetics and Animal Breeding, Poznan University of Life Sciences, Wolynska 33, Poznan, Poland. strabel@up.poznan.pl.
  • Mucha S; Department of Genetics and Animal Breeding, Poznan University of Life Sciences, Wolynska 33, Poznan, Poland.
  • Sell-Kubiak E; Department of Genetics and Animal Breeding, Poznan University of Life Sciences, Wolynska 33, Poznan, Poland.
Sci Rep ; 8(1): 15164, 2018 10 11.
Article en En | MEDLINE | ID: mdl-30310168
The global temperatures are increasing. This increase is partly due to methane (CH4) production from ruminants, including dairy cattle. Recent studies on dairy cattle have revealed the existence of a heritable variation in CH4 production that enables mitigation strategies based on selective breeding. We have exploited the available heritable variation to study the genetic architecture of CH4 production and detected genomic regions affecting CH4 production. Although the detected regions explained only a small proportion of the heritable variance, we showed that potential QTL regions affecting CH4 production were located within QTLs related to feed efficiency, milk-related traits, body size and health status. Five candidate genes were found: CYP51A1 on BTA 4, PPP1R16B on BTA 13, and NTHL1, TSC2, and PKD1 on BTA 25. These candidate genes were involved in a number of metabolic processes that are possibly related to CH4 production. One of the most promising candidate genes (PKD1) was related to the development of the digestive tract. The results indicate that CH4 production is a highly polygenic trait.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bovinos / Sitios de Carácter Cuantitativo / Tracto Gastrointestinal / Metano Tipo de estudio: Prognostic_studies / Risk_factors_studies Aspecto: Patient_preference Límite: Animals Idioma: En Revista: Sci Rep Año: 2018 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bovinos / Sitios de Carácter Cuantitativo / Tracto Gastrointestinal / Metano Tipo de estudio: Prognostic_studies / Risk_factors_studies Aspecto: Patient_preference Límite: Animals Idioma: En Revista: Sci Rep Año: 2018 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Reino Unido