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Effect of oral trazodone on the minimum alveolar concentration of isoflurane in dogs.
Hoffman, Elizabeth A; Aarnes, Turi K; Ricco Pereira, Carolina H; Lerche, Phillip; Bednarski, Richard M; McLoughlin, Mary A.
Afiliación
  • Hoffman EA; Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH, USA.
  • Aarnes TK; Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH, USA. Electronic address: aarnes.1@osu.edu.
  • Ricco Pereira CH; Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH, USA.
  • Lerche P; Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH, USA.
  • Bednarski RM; Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH, USA.
  • McLoughlin MA; Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH, USA.
Vet Anaesth Analg ; 45(6): 754-759, 2018 Nov.
Article en En | MEDLINE | ID: mdl-30297130
OBJECTIVE: To determine the effect of oral trazodone on the minimum alveolar concentration (MAC) of isoflurane in dogs. STUDY DESIGN: Prospective blinded, single-observer, randomized crossover experimental study. ANIMALS: Six adult (age 6.8 ± 1.6 months) healthy dogs (three males and three females), weighing 24.8 ± 3.4 kg (mean ± standard deviation). METHODS: Each dog was anesthetized twice with a minimum of 7 days between anesthetic episodes. Dogs were randomly assigned to be administered two treatments in a crossover design: premedication with trazodone (8 mg kg-1; TRAZ-ISO) orally 2 hours prior to an anesthetic episode or no (ISO). Dogs were anesthetized with intravenous propofol (6 mg kg-1) and isoflurane in >95% oxygen. Isoflurane MAC was determined using an iterative bracketing technique with electrodes placed in the buccal mucosa. Hemodynamic variables were compared at the lowest end-tidal isoflurane concentration at which each dog did not respond. A paired t test was used to assess the effect of treatment on outcome variables with significance set to a value of p < 0.05. RESULTS: The MAC concentration (mean ± standard deviation) in dogs administered TRAZ-ISO was 0.85 ± 0.17% compared with 1.02 ± 0.11% in those administered ISO (p = 0.01, 95% confidence interval -0.25 to -0.05), resulting in a mean MAC reduction of 17 ± 12%. There were no differences in hemodynamic variables between treatments. CONCLUSIONS AND CLINICAL RELEVANCE: Premedication of dogs with oral trazodone (8 mg kg-1) 2 hours prior to anesthetic induction has a significant isoflurane MAC sparing effect with no significant observed hemodynamic benefit.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Alveolos Pulmonares / Trazodona / Inhibidores Selectivos de la Recaptación de Serotonina / Anestésicos por Inhalación / Isoflurano Tipo de estudio: Observational_studies Límite: Animals Idioma: En Revista: Vet Anaesth Analg Asunto de la revista: ANESTESIOLOGIA / MEDICINA VETERINARIA Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Alveolos Pulmonares / Trazodona / Inhibidores Selectivos de la Recaptación de Serotonina / Anestésicos por Inhalación / Isoflurano Tipo de estudio: Observational_studies Límite: Animals Idioma: En Revista: Vet Anaesth Analg Asunto de la revista: ANESTESIOLOGIA / MEDICINA VETERINARIA Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos