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Genetic characterization of measles virus genotype D6 subacute sclerosing panencephalitis case, Alberta, Canada.
Pabbaraju, K; Fonseca, K; Wong, S; Koch, M W; Joseph, J T; Tipples, G A; Tellier, R.
Afiliación
  • Pabbaraju K; Provincial Laboratory for Public Health, Calgary, Alberta, Canada. kanti.pabbaraju@albertahealthservices.ca.
  • Fonseca K; Provincial Laboratory for Public Health, Calgary, Alberta, Canada.
  • Wong S; Department of Microbiology, Immunology and Infectious Diseases, University of Calgary, Calgary, Alberta, Canada.
  • Koch MW; Provincial Laboratory for Public Health, Calgary, Alberta, Canada.
  • Joseph JT; Departments of Clinical Neurosciences and Community Health Sciences, University of Calgary, Calgary, Alberta, Canada.
  • Tipples GA; Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, Alberta, Canada.
  • Tellier R; Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta, Canada.
J Neurovirol ; 24(6): 720-729, 2018 12.
Article en En | MEDLINE | ID: mdl-30291564
Subacute sclerosing panencephalitis (SSPE) is a progressive and eventually fatal neurological disease arising from a persistent infection with measles virus (MV) acquired at a young age. SSPE measles virus strains are defective and unable to produce progeny virions, due to multiple and extensive mutations in a number of key genes. We sequenced the full MV genome from our recently reported SSPE case, which typed as genotype D6, and compared it with other genotype D6 wild type and SSPE sequences. The Alberta D6 strain was significantly different from other reported SSPE D6 sequences. Mutations were observed in all the genes of the Alberta strain, with the greatest sequence divergence noted in the M gene with 17.6% nucleotide and 31% amino acid variation. The L gene showed the least variation with 1.3% nucleotide and 0.7% amino acid differences respectively. The nucleotide variability for 15,672 bases of the complete genome compared to the wild type and other SSPE D6 strains was around 3%.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Panencefalitis Esclerosante Subaguda / Virus SSPE Límite: Adult / Female / Humans / Pregnancy País/Región como asunto: America do norte Idioma: En Revista: J Neurovirol Asunto de la revista: NEUROLOGIA / VIROLOGIA Año: 2018 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Panencefalitis Esclerosante Subaguda / Virus SSPE Límite: Adult / Female / Humans / Pregnancy País/Región como asunto: America do norte Idioma: En Revista: J Neurovirol Asunto de la revista: NEUROLOGIA / VIROLOGIA Año: 2018 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos