Papaverine-induced positive inotropism with failure to increase cyclic AMP in rat atria.
Eur J Pharmacol
; 131(1): 141-4, 1986 Nov 12.
Article
en En
| MEDLINE
| ID: mdl-3028824
Phosphodiesterase inhibition by papaverine is likely to play a minor role in the rat atrial inotropic response because non-significant changes in cyclic AMP were obtained. Isoprenaline however raised the nucleotide levels three-fold and up to seventeen-fold when papaverine was added in a similar preparation. A prominent effect of papaverine was to lengthen relaxation instead of shortening it as did isoprenaline. The results suggest different sites of action, although overlapping effects cannot be excluded.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Papaverina
/
AMP Cíclico
/
Contracción Miocárdica
/
Miocardio
Límite:
Animals
Idioma:
En
Revista:
Eur J Pharmacol
Año:
1986
Tipo del documento:
Article
Pais de publicación:
Países Bajos