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Iron overload in myelodysplastic syndromes: Evidence based guidelines from the Canadian consortium on MDS.
Leitch, Heather A; Buckstein, Rena; Zhu, Nancy; Nevill, Thomas J; Yee, Karen W L; Leber, Brian; Keating, Mary-Margaret; St Hilaire, Eve; Kumar, Rajat; Delage, Robert; Geddes, Michelle; Storring, John M; Shamy, April; Elemary, Mohamed; Wells, Richard A.
Afiliación
  • Leitch HA; Hematology, St. Paul's Hospital and the University of British Columbia, Vancouver, BC, Canada. Electronic address: hleitch@providencehematology.com.
  • Buckstein R; Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.
  • Zhu N; Hematology/Oncology, University of Alberta, Edmonton, Alberta, Canada.
  • Nevill TJ; Leukemia/BMT Program of British Columbia, Division of Hematology, Vancouver, BC, Canada.
  • Yee KWL; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
  • Leber B; McMaster University, Hamilton, Ontario, Canada.
  • Keating MM; Queen Elizabeth II Health Sciences Center, Halifax, Nova Scotia, Canada.
  • St Hilaire E; Centre d'Oncologie, Dr-Leon-Richard, Moncton, New Brunswick, Canada.
  • Kumar R; Hematology/Oncology, CancerCare Manitoba, Winnipeg, Manitoba, Canada.
  • Delage R; Hematology Department, Centre Hospitalier Universitaire, Laval University, Quebec, QC, Canada.
  • Geddes M; Department of Medicine/Hematology, Foothills Medical Centre, Calgary, Alberta, Canada.
  • Storring JM; McGill University Health Centre, Montreal, Quebec, Canada.
  • Shamy A; Sir Mortimer B Davis Hospital, McGill University, Montreal, Quebec, Canada.
  • Elemary M; Saskatoon Cancer Center, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
  • Wells RA; Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.
Leuk Res ; 74: 21-41, 2018 11.
Article en En | MEDLINE | ID: mdl-30286330
In 2008 the first evidence-based Canadian consensus guideline addressing the diagnosis, monitoring and management of transfusional iron overload in patients with myelodysplastic syndromes (MDS) was published. The Canadian Consortium on MDS, comprised of hematologists from across Canada with a clinical and academic interest in MDS, reconvened to update these guidelines. A literature search was updated in 2017; topics reviewed include mechanisms of iron overload induced cellular damage, evidence for clinical endpoints impacted by iron overload including organ dysfunction, infections, marrow failure, overall survival, acute myeloid leukemia progression, and endpoints around hematopoietic stem-cell transplant. Evidence for an impact of iron reduction on the same endpoints is discussed, guidelines are updated, and areas identified where evidence is suboptimal. The guidelines address common questions around the diagnosis, workup and management of iron overload in clinical practice, and take the approach of who, when, why and how to treat iron overload in MDS. Practical recommendations for treatment and monitoring are made. Evidence levels and grading of recommendations are provided for all clinical endpoints examined.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Síndromes Mielodisplásicos / Sobrecarga de Hierro Tipo de estudio: Clinical_trials / Diagnostic_studies / Guideline / Prognostic_studies Límite: Female / Humans / Male País/Región como asunto: America do norte Idioma: En Revista: Leuk Res Año: 2018 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Síndromes Mielodisplásicos / Sobrecarga de Hierro Tipo de estudio: Clinical_trials / Diagnostic_studies / Guideline / Prognostic_studies Límite: Female / Humans / Male País/Región como asunto: America do norte Idioma: En Revista: Leuk Res Año: 2018 Tipo del documento: Article Pais de publicación: Reino Unido