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Molecular phylogenetics of Newcastle disease viruses isolated from vaccinated flocks during outbreaks in Southern India reveals circulation of a novel sub-genotype.
Gowthaman, Vasudevan; Ganesan, Venkateswaran; Gopala Krishna Murthy, Thippicettipalayam Ramasamy; Nair, Sowmya; Yegavinti, Nagarjuna; Saraswathy, Puzhavakath Vaidyanathan; Suresh Kumar, Ganesan; Udhayavel, Shanmugasunderam; Senthilvel, Kandasamy; Subbiah, Madhuri.
Afiliación
  • Gowthaman V; Poultry Disease Diagnosis and Surveillance Laboratory, Veterinary College and Research Institute Campus, Tamil Nadu Veterinary and Animal Sciences University, Namakkal, India.
  • Ganesan V; National Institute of Animal Biotechnology, Hyderabad, India.
  • Gopala Krishna Murthy TR; Poultry Disease Diagnosis and Surveillance Laboratory, Veterinary College and Research Institute Campus, Tamil Nadu Veterinary and Animal Sciences University, Namakkal, India.
  • Nair S; National Institute of Animal Biotechnology, Hyderabad, India.
  • Yegavinti N; National Institute of Animal Biotechnology, Hyderabad, India.
  • Saraswathy PV; National Institute of Animal Biotechnology, Hyderabad, India.
  • Suresh Kumar G; Poultry Disease Diagnosis and Surveillance Laboratory, Veterinary College and Research Institute Campus, Tamil Nadu Veterinary and Animal Sciences University, Namakkal, India.
  • Udhayavel S; Poultry Disease Diagnosis and Surveillance Laboratory, Veterinary College and Research Institute Campus, Tamil Nadu Veterinary and Animal Sciences University, Namakkal, India.
  • Senthilvel K; Poultry Disease Diagnosis and Surveillance Laboratory, Veterinary College and Research Institute Campus, Tamil Nadu Veterinary and Animal Sciences University, Namakkal, India.
  • Subbiah M; National Institute of Animal Biotechnology, Hyderabad, India.
Transbound Emerg Dis ; 66(1): 363-372, 2019 Jan.
Article en En | MEDLINE | ID: mdl-30281910
Newcastle disease (ND) is an economically important, contagious poultry viral disease reported across the globe. In India, ND is endemic and episodes of ND outbreaks despite strict vaccinations are not uncommon. We isolated and characterized seven ND viruses from vaccinated commercial poultry farms during severe disease outbreaks in Tamil Nadu, in Southern India, between April 2015 and June 2016. All the seven isolates were categorized as virulent by mean death time (48-54 hr) in embryonated chicken eggs. Also, their sequences carried the virulence signature of multi-basic amino acid residues in their fusion protein cleavage site (RRQ/RR/KRF). Phylogenetic and evolutionary distance analyses revealed circulation of a novel sub-genotype of genotype XIII, class II ND viruses, herein proposed as sub-genotype XIIIe. The genetic divergence between the circulating virulent strains and the vaccine strains could possibly explain the disease outbreak in the vaccinated flocks. Further, our study signifies the need to implement routine epidemiological surveillance and to revisit the current vaccination program.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Virus de la Enfermedad de Newcastle / Pollos / Proteínas Virales de Fusión / Genotipo Límite: Animals País/Región como asunto: Asia Idioma: En Revista: Transbound Emerg Dis Asunto de la revista: MEDICINA VETERINARIA Año: 2019 Tipo del documento: Article País de afiliación: India Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Virus de la Enfermedad de Newcastle / Pollos / Proteínas Virales de Fusión / Genotipo Límite: Animals País/Región como asunto: Asia Idioma: En Revista: Transbound Emerg Dis Asunto de la revista: MEDICINA VETERINARIA Año: 2019 Tipo del documento: Article País de afiliación: India Pais de publicación: Alemania