Your browser doesn't support javascript.
loading
Free Testosterone Reflects Metabolic as well as Ovarian Disturbances in Subfertile Oligomenorrheic Women.
Antonio, L; Pauwels, S; Laurent, M R; Vanschoubroeck, D; Jans, I; Billen, J; Claessens, F; Decallonne, B; De Neubourg, Diane; Vermeersch, P; Vanderschueren, D.
Afiliación
  • Antonio L; Department of Chronic Diseases, Metabolism and Ageing (CHROMETA), Laboratory of Clinical and Experimental Endocrinology, KU Leuven, Leuven, Belgium.
  • Pauwels S; Department of Endocrinology, University Hospitals Leuven, Leuven, Belgium.
  • Laurent MR; Department of Laboratory Medicine, University Hospitals Leuven, Leuven, Belgium.
  • Vanschoubroeck D; Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium.
  • Jans I; Department of Cellular and Molecular Medicine, Laboratory of Molecular Endocrinology, KU Leuven, Leuven, Belgium.
  • Billen J; Department of Obstetrics and Gynecology, University Hospitals Leuven, Leuven, Belgium.
  • Claessens F; Department of Laboratory Medicine, University Hospitals Leuven, Leuven, Belgium.
  • Decallonne B; Department of Laboratory Medicine, University Hospitals Leuven, Leuven, Belgium.
  • De Neubourg D; Department of Cellular and Molecular Medicine, Laboratory of Molecular Endocrinology, KU Leuven, Leuven, Belgium.
  • Vermeersch P; Department of Chronic Diseases, Metabolism and Ageing (CHROMETA), Laboratory of Clinical and Experimental Endocrinology, KU Leuven, Leuven, Belgium.
  • Vanderschueren D; Department of Endocrinology, University Hospitals Leuven, Leuven, Belgium.
Int J Endocrinol ; 2018: 7956951, 2018.
Article en En | MEDLINE | ID: mdl-30275830
BACKGROUND: Diagnosing polycystic ovary syndrome (PCOS) is based on ovulatory dysfunction, ovarian ultrasound data, and androgen excess. Total testosterone is frequently used to identify androgen excess, but testosterone is mainly bound to sex hormone-binding globulin (SHBG) and albumin. Only 1-2% of nonprotein-bound testosterone (so-called free testosterone) is biologically active and responsible for androgen action. Moreover, automated immunoassays which are frequently used for female testosterone measurements are inaccurate. OBJECTIVE: To assess the clinical usefulness of liquid chromatography-tandem mass spectrometry measured testosterone and calculated free testosterone in subfertile women attending a fertility clinic with oligomenorrhea and suspected PCOS. METHODS: Hormonal and metabolic parameters were evaluated, and ovarian ultrasound was performed. Total testosterone was measured by liquid chromatography-tandem mass spectrometry. Free testosterone was calculated from total testosterone and SHBG. RESULTS: Sixty-six women were included in the study. Total testosterone was associated with ovarian volume and antral follicle count but not with metabolic parameters. However, SHBG and calculated free testosterone were associated with both ovarian ultrasound and metabolic parameters, such as BMI and insulin resistance. CONCLUSIONS: Assessing SHBG and free testosterone is important in evaluating androgen excess in subfertile women with ovulatory dysfunction and suspected PCOS, as it reflects both ovarian and metabolic disturbances.
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Int J Endocrinol Año: 2018 Tipo del documento: Article País de afiliación: Bélgica Pais de publicación: Egipto
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Int J Endocrinol Año: 2018 Tipo del documento: Article País de afiliación: Bélgica Pais de publicación: Egipto