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A meta-analysis of blood lead levels in India and the attributable burden of disease.
Ericson, Bret; Dowling, Russell; Dey, Subhojit; Caravanos, Jack; Mishra, Navya; Fisher, Samantha; Ramirez, Myla; Sharma, Promila; McCartor, Andrew; Guin, Pradeep; Taylor, Mark Patrick; Fuller, Richard.
Afiliación
  • Ericson B; Pure Earth, 475 Riverside Drive, Suite 860, New York, NY 10025, USA; Department of Environmental Sciences, Faculty of Science and Engineering, Macquarie University, North Ryde, Sydney, NSW 2109, Australia. Electronic address: bret@pureearth.org.
  • Dowling R; Pure Earth, 475 Riverside Drive, Suite 860, New York, NY 10025, USA.
  • Dey S; Indian Institute of Public Health, Plot No. 47, Sector 44, Institutional Area Gurgaon, 122002 Delhi, Delhi NCR, India.
  • Caravanos J; Pure Earth, 475 Riverside Drive, Suite 860, New York, NY 10025, USA; College of Global Public Health, New York University, 41 East 11th Street, New York, NY 10003, USA.
  • Mishra N; Public Health Foundation of India, Plot No. 47, Sector 44, Institutional Area Gurgaon, 122002, Delhi NCR, India.
  • Fisher S; Pure Earth, 475 Riverside Drive, Suite 860, New York, NY 10025, USA.
  • Ramirez M; Pure Earth, 475 Riverside Drive, Suite 860, New York, NY 10025, USA.
  • Sharma P; Pure Earth, 475 Riverside Drive, Suite 860, New York, NY 10025, USA.
  • McCartor A; Pure Earth, 475 Riverside Drive, Suite 860, New York, NY 10025, USA.
  • Guin P; Jindal School of Government and Public Policy, O.P. Jindal Global University, Sonipat Narela Road, Sonipat 131001, Haryana, India.
  • Taylor MP; Department of Environmental Sciences, Faculty of Science and Engineering, Macquarie University, North Ryde, Sydney, NSW 2109, Australia.
  • Fuller R; Pure Earth, 475 Riverside Drive, Suite 860, New York, NY 10025, USA.
Environ Int ; 121(Pt 1): 461-470, 2018 12.
Article en En | MEDLINE | ID: mdl-30273869
Multiple studies in India have found elevated blood lead levels (BLLs) in target populations. However the data have not yet been evaluated to understand population-wide exposure levels. We used arithmetic mean blood lead data published from 2010 to 2018 on Indian populations to calculate the average BLLs for multiple subgroups. We then calculated the attributable disease burden in IQ decrement and Disability Adjusted Life Years (DALYs). Our Pubmed search yielded 1066 articles. Of these, 31 studies representing the BLLs of 5472 people in 9 states met our study criteria. Evaluating these, we found a mean BLL of 6.86 µg/dL (95% CI: 4.38-9.35) in children and 7.52 µg/dL (95% CI: 5.28-9.76) in non-occupationally exposed adults. We calculated that these exposures resulted in 4.9 million DALYs (95% CI: 3.9-5.6) in the states we evaluated. Population-wide BLLs in India remain elevated despite regulatory action to eliminate leaded petrol, the most significant historical source. The estimated attributable disease burden is larger than previously calculated, particularly with regard to associated intellectual disability outcomes in children. Larger population-wide BLL studies are required to inform future calculations. Policy responses need to be developed to mitigate the worst exposures.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Costo de Enfermedad / Años de Vida Ajustados por Calidad de Vida / Exposición a Riesgos Ambientales / Contaminantes Ambientales / Plomo Tipo de estudio: Systematic_reviews Aspecto: Patient_preference Límite: Humans País/Región como asunto: Asia Idioma: En Revista: Environ Int Año: 2018 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Costo de Enfermedad / Años de Vida Ajustados por Calidad de Vida / Exposición a Riesgos Ambientales / Contaminantes Ambientales / Plomo Tipo de estudio: Systematic_reviews Aspecto: Patient_preference Límite: Humans País/Región como asunto: Asia Idioma: En Revista: Environ Int Año: 2018 Tipo del documento: Article Pais de publicación: Países Bajos