Nickel-Catalyzed Cross-Dehydrogenative Coupling of &#945;-C(sp<sup>3</sup>)-H Bonds in N-Methylamides with C(sp<sup>3</sup>)-H Bonds in Cyclic Alkanes.

Li, Ze-Lin; Sun, Kang-Kang; Cai, Chun

Nickel-Catalyzed Cross-Dehydrogenative Coupling of α-C(sp³)-H Bonds in N-Methylamides with C(sp³)-H Bonds in Cyclic Alkanes.

Li, Ze-Lin; Sun, Kang-Kang; Cai, Chun.

Afiliación

Li ZL; Chemical Engineering College , Nanjing University of Science and Technology , Nanjing 210094 , People's Republic of China.
Sun KK; Chemical Engineering College , Nanjing University of Science and Technology , Nanjing 210094 , People's Republic of China.
Cai C; Chemical Engineering College , Nanjing University of Science and Technology , Nanjing 210094 , People's Republic of China.

Org Lett ; 20(20): 6420-6424, 2018 10 19.

Article en En | MEDLINE | ID: mdl-30272983

RESUMEN

A nickel-catalyzed cross-dehydrogenative coupling reaction of α-C(sp3)-H bonds in N-methylamides with C(sp3)-H bonds from cyclic alkanes has been developed, which offers a cheap transition-metal-catalyzed C-H activation method for amides without the requirement for any extraneous directing group. This new strategy is highly selective and tolerates a variety of functional groups. Mechanistic investigations into the reaction process are also described in detail.

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Org Lett Asunto de la revista: BIOQUIMICA Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos

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