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Enhanced bioactivity and efficient delivery of quercetin through nanoliposomal encapsulation using rice bran phospholipids.
Rodriguez, Evelyn B; Almeda, Ronaniel A; Vidallon, Mark Louis P; Reyes, Charisse T.
Afiliación
  • Rodriguez EB; Institute of Chemistry, College of Arts and Sciences, University of the Philippines Los Baños, Los Baños, Philippines.
  • Almeda RA; Institute of Chemistry, College of Arts and Sciences, University of the Philippines Los Baños, Los Baños, Philippines.
  • Vidallon MLP; Institute of Chemistry, College of Arts and Sciences, University of the Philippines Los Baños, Los Baños, Philippines.
  • Reyes CT; Faculty of Education, University of the Philippines Open University, Los Baños, Philippines.
J Sci Food Agric ; 99(4): 1980-1989, 2019 Mar 15.
Article en En | MEDLINE | ID: mdl-30270448
BACKGROUND: Quercetin is a phenolic compound occurring in many food plants and agricultural crops. It is reported to possess various health-promoting properties. However, the poor bioavailability of quercetin, due to its low aqueous solubility and its degradation during digestion, limits its nutraceutical applications. This study aimed to encapsulate quercetin in nanoliposomes using rice-bran phospholipids for its efficient delivery and controlled release, the protection of its structural stability, and enhancement of its bioactivity. RESULTS: Nanoliposomal encapsulation of quercetin by thin film-sonication method yielded spherical nanoparticles (157.33 ± 23.78 nm) with high encapsulation efficiency (84.92 ± 0.78%). Storage stability studies showed that nanoliposomal quercetin was stable at 4 °C and 27 °C for 6 and 5 months, respectively, as indicated by unchanged antioxidant activity and quercetin retention. Nanoliposomal quercetin showed a slow, limited release pattern in simulated gastric fluid (SGF), and an initial burst release followed by a slow constant releasing pattern in simulated intestinal fluid (SIF). A 1004-fold increase in 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical-scavenging activity was observed in quercetin nanoliposomes (SC50 = 4.04 ± 0.01 ppm) compared to non-encapsulated quercetin (SC50 = 4053.03 ± 5.61 ppm). Similarly, the anti-angiogenic activity of quercetin, as evaluated by duck embryo chorioallantoic membrane (CAM) assay, was enhanced twofold to fivefold by nanoliposomal encapsulation. CONCLUSION: This study showed that nanoliposomal encapsulation in rice-bran phospholipids enhanced the radical-scavenging and anti-angiogenic activities of quercetin. Furthermore, this study demonstrated that nanoliposomes can serve as efficient oral delivery system for quercetin. © 2018 Society of Chemical Industry.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fosfolípidos / Quercetina / Oryza / Portadores de Fármacos / Extractos Vegetales / Composición de Medicamentos Tipo de estudio: Evaluation_studies Límite: Humans Idioma: En Revista: J Sci Food Agric Año: 2019 Tipo del documento: Article País de afiliación: Filipinas Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fosfolípidos / Quercetina / Oryza / Portadores de Fármacos / Extractos Vegetales / Composición de Medicamentos Tipo de estudio: Evaluation_studies Límite: Humans Idioma: En Revista: J Sci Food Agric Año: 2019 Tipo del documento: Article País de afiliación: Filipinas Pais de publicación: Reino Unido