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Pervasion of beta-tricalcium phosphate with nanodiamond particles yields efficient and safe bone replacement material amenable for biofunctionalization and application in large-size osseous defect healing.
Stigler, Robert G; Schimke, Magdalena M; Bigus, Simon; Steinmüller-Nethl, Doris; Tillmann, Katharina; Lepperdinger, Günter.
Afiliación
  • Stigler RG; Medical University Innsbruck, Department of Oral and Maxillofacial Surgery, Innsbruck, Austria. Electronic address: Robert.stigler@i-med.ac.at.
  • Schimke MM; University of Salzburg, Dept. Biosciences, Salzburg, Austria.
  • Bigus S; Medical University Innsbruck, Department of Oral and Maxillofacial Surgery, Innsbruck, Austria.
  • Steinmüller-Nethl D; DiaCoating GmbH, Werkstätte Wattens, Wattens, Austria.
  • Tillmann K; General Hospital of Vienna, Center for Biomedical Research, AKH Wien, Bauteil 24, Wien, Austria.
  • Lepperdinger G; University of Salzburg, Dept. Biosciences, Salzburg, Austria.
Nanomedicine ; 16: 250-257, 2019 02.
Article en En | MEDLINE | ID: mdl-30267872
Biofunctionalization of scaffold materials can enable the healing of large bone defects. In case of minimally invasive guided-bone regeneration (GBR), limitations are however hard-to-control side effects related to the potential release of biofactors into the systemic environment. Biofactors can be stably bound to nanodiamond particles (ND) through physisorption. We therefore tested the biological and clinical effects of refining beta-tricalcium phosphate (ßTCP) with ND in vitro and in vivo. In vitro, ßTCP carrying 4% ND resulted in enhanced attachment of mesenchymal stem cells. When assessing GBR after lateral augmentation of the mandible in sheep showed that ND in ßTCP resulted in a consistently steady bone formation when compared to pure ßTCP, demonstrating the biological inert behavior and the potential clinical safety of ND.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fosfatos de Calcio / Andamios del Tejido / Nanodiamantes Límite: Animals Idioma: En Revista: Nanomedicine Asunto de la revista: BIOTECNOLOGIA Año: 2019 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fosfatos de Calcio / Andamios del Tejido / Nanodiamantes Límite: Animals Idioma: En Revista: Nanomedicine Asunto de la revista: BIOTECNOLOGIA Año: 2019 Tipo del documento: Article Pais de publicación: Estados Unidos