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Silica and carbon decorated silica nanosheet impact on primary human immune cells.
Al Soubaihi, Rola Mohammad; Furesi, Giulia; Saoud, Khaled Mohammad; Al-Muhtaseb, Shaheen A; Khatat, Ahmed El; Delogu, Lucia Gemma; Dutta, Joydeep.
Afiliación
  • Al Soubaihi RM; Functional Materials, Department of Applied Physics, The Royal Institute of Technology, School of Engineering Sciences, Isafjordsgatan 22, SE-164 40 Kista Stockholm, Sweden.
  • Furesi G; University of Sassari, Sassari, 07100, Italy.
  • Saoud KM; Liberal Arts and Sciences Program, Virginia Commonwealth University in Qatar, P.O. Box 8095, Doha, Qatar. Electronic address: s2kmsaou@vcu.edu.
  • Al-Muhtaseb SA; Department of Chemical Engineering, Qatar University, P.O. Box 2713, Doha, Qatar.
  • Khatat AE; Department of Chemical Engineering, Qatar University, P.O. Box 2713, Doha, Qatar.
  • Delogu LG; University of Sassari, Sassari, 07100, Italy; Fondazione Citta' Della Speranza, Istituto di Ricerca Pediatrica, Padova, 35129, Italy. Electronic address: lgdelogu@uniss.it.
  • Dutta J; Functional Materials, Department of Applied Physics, The Royal Institute of Technology, School of Engineering Sciences, Isafjordsgatan 22, SE-164 40 Kista Stockholm, Sweden.
Colloids Surf B Biointerfaces ; 172: 779-789, 2018 Dec 01.
Article en En | MEDLINE | ID: mdl-30266012
Silica nanosheets (SiO2 NS) are considered to be a promising material in clinical practice for diagnosis and therapy applications. However, an appropriate surface functionalization is essential to guarantee high biocompatibility and molecule loading ability. Although SiO2 NS are chemically stable, its effects on immune systems are still being explored. In this work, we successfully synthesized a novel 2D multilayer SiO2 NS and SiO2 NS coated with carbon (C/SiO2 NS), and evaluated their impact on human Peripheral Blood Mononuclear Cells (PBMCs) and some immune cell subpopulations. We demonstrated that the immune response is strongly dependent on the surface functionalities of the SiO2 NS. Ex vivo experiments showed an increase in biocompatibility of C/SiO2 NS compared to SiO2 NS, resulting in a lowering of hemoglobin release together with a reduction in cellular toxicity and cellular activation. However, none of them are directly involved in the activation of the acute inflammation process with a consequent release of pro-inflammatory cytokines. The obtained results provide an important direction towards the biomedical applications of silica nanosheets, rendering them an attractive material for the development of future immunological therapies.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carbono / Linfocitos / Dióxido de Silicio / Nanopartículas Límite: Adult / Humans / Middle aged Idioma: En Revista: Colloids Surf B Biointerfaces Asunto de la revista: QUIMICA Año: 2018 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carbono / Linfocitos / Dióxido de Silicio / Nanopartículas Límite: Adult / Humans / Middle aged Idioma: En Revista: Colloids Surf B Biointerfaces Asunto de la revista: QUIMICA Año: 2018 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Países Bajos