Cu and Zn coordination to amyloid peptides: From fascinating chemistry to debated pathological relevance.
Coord Chem Rev
; 375: 38-55, 2018 Sep 15.
Article
en En
| MEDLINE
| ID: mdl-30262932
Several diseases share misfolding of different peptides and proteins as a key feature for their development. This is the case of important neurodegenerative diseases such as Alzheimer's and Parkinson's diseases and type II diabetes mellitus. Even more, metal ions such as copper and zinc might play an important role upon interaction with amyloidogenic peptides and proteins, which could impact their aggregation and toxicity abilities. In this review, the different coordination modes proposed for copper and zinc with amyloid-ß, α-synuclein and IAPP will be reviewed as well as their impact on the aggregation, and ROS production in the case of copper. In addition, a special focus will be given to the mutations that affect metal binding and lead to familial cases of the diseases. Different modifications of the peptides that have been observed in vivo and could be relevant for the coordination of metal ions are also described.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Coord Chem Rev
Año:
2018
Tipo del documento:
Article
País de afiliación:
Francia
Pais de publicación:
Suiza