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Urine-derived lymphocytes as a non-invasive measure of the bladder tumor immune microenvironment.
Wong, Yien Ning Sophia; Joshi, Kroopa; Khetrapal, Pramit; Ismail, Mazlina; Reading, James L; Sunderland, Mariana Werner; Georgiou, Andrew; Furness, Andrew J S; Ben Aissa, Assma; Ghorani, Ehsan; Oakes, Theres; Uddin, Imran; Tan, Wei Shen; Feber, Andrew; McGovern, Ursula; Swanton, Charles; Freeman, Alex; Marafioti, Teresa; Briggs, Timothy P; Kelly, John D; Powles, Thomas; Peggs, Karl S; Chain, Benjamin M; Linch, Mark D; Quezada, Sergio A.
Afiliación
  • Wong YNS; Cancer Immunology Unit, University College London (UCL) Cancer Institute, London, England, UK.
  • Joshi K; Research Department of Haematology, UCL Cancer Institute, London, England, UK.
  • Khetrapal P; Department of Oncology, UCL Cancer Institute, London, England, UK.
  • Ismail M; Department of Oncology, University College London Hospital, London, England, UK.
  • Reading JL; Cancer Immunology Unit, University College London (UCL) Cancer Institute, London, England, UK.
  • Sunderland MW; Research Department of Haematology, UCL Cancer Institute, London, England, UK.
  • Georgiou A; Division of Infection and Immunity, University College London, London, England, UK.
  • Furness AJS; Department of Medical Oncology, The Royal Marsden NHS Foundation Trust, London, England, UK.
  • Ben Aissa A; Department of Urology, University College London Hospital at Westmoreland Street, London, England, UK.
  • Ghorani E; Division of Surgical and Interventional Sciences, University College London, London, England, UK.
  • Oakes T; Division of Infection and Immunity, University College London, London, England, UK.
  • Uddin I; Cancer Immunology Unit, University College London (UCL) Cancer Institute, London, England, UK.
  • Tan WS; Research Department of Haematology, UCL Cancer Institute, London, England, UK.
  • Feber A; Cancer Immunology Unit, University College London (UCL) Cancer Institute, London, England, UK.
  • McGovern U; Research Department of Haematology, UCL Cancer Institute, London, England, UK.
  • Swanton C; Cancer Immunology Unit, University College London (UCL) Cancer Institute, London, England, UK.
  • Freeman A; Research Department of Haematology, UCL Cancer Institute, London, England, UK.
  • Marafioti T; Cancer Immunology Unit, University College London (UCL) Cancer Institute, London, England, UK.
  • Briggs TP; Research Department of Haematology, UCL Cancer Institute, London, England, UK.
  • Kelly JD; Department of Medical Oncology, The Royal Marsden NHS Foundation Trust, London, England, UK.
  • Powles T; Cancer Immunology Unit, University College London (UCL) Cancer Institute, London, England, UK.
  • Peggs KS; Research Department of Haematology, UCL Cancer Institute, London, England, UK.
  • Chain BM; Cancer Immunology Unit, University College London (UCL) Cancer Institute, London, England, UK.
  • Linch MD; Research Department of Haematology, UCL Cancer Institute, London, England, UK.
  • Quezada SA; Division of Infection and Immunity, University College London, London, England, UK.
J Exp Med ; 215(11): 2748-2759, 2018 11 05.
Article en En | MEDLINE | ID: mdl-30257862
Despite the advances in cancer immunotherapy, only a fraction of patients with bladder cancer exhibit responses to checkpoint blockade, highlighting a need to better understand drug resistance and identify rational immunotherapy combinations. However, accessibility to the tumor prior and during therapy is a major limitation in understanding the immune tumor microenvironment (TME). Herein, we identified urine-derived lymphocytes (UDLs) as a readily accessible source of T cells in 32 patients with muscle invasive bladder cancer (MIBC). We observed that effector CD8+ and CD4+ cells and regulatory T cells within the urine accurately map the immune checkpoint landscape and T cell receptor repertoire of the TME. Finally, an increased UDL count, specifically high expression of PD-1 (PD-1hi) on CD8+ at the time of cystectomy, was associated with a shorter recurrence-free survival. UDL analysis represents a dynamic liquid biopsy that is representative of the bladder immune TME that may be used to identify actionable immuno-oncology (IO) targets with potential prognostic value in MIBC.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Orina / Neoplasias de la Vejiga Urinaria / Linfocitos T CD4-Positivos / Linfocitos T CD8-positivos / Microambiente Tumoral Límite: Female / Humans / Male Idioma: En Revista: J Exp Med Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Orina / Neoplasias de la Vejiga Urinaria / Linfocitos T CD4-Positivos / Linfocitos T CD8-positivos / Microambiente Tumoral Límite: Female / Humans / Male Idioma: En Revista: J Exp Med Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos